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Basic structure of a peroxisome Distribution of peroxisomes (white) in HEK 293 cells during mitosis Peroxisome in rat neonatal cardiomyocyte. A peroxisome (IPA: [pɛɜˈɹɒksɪˌsoʊm]) [1] is a membrane-bound organelle, a type of microbody, found in the cytoplasm of virtually all eukaryotic cells. [2] [3] Peroxisomes are oxidative organelles.
Perfluorodecanoic acid (PFDA) is a chemical of significant concern due to its classification as a Persistent, Bioaccumulative, and Toxic (PBT) substance. It has been identified as a potential carcinogen, with an acute oral toxicity estimate indicating a lethal dose for 50% of rats at 57 mg/kg.
The toxicity, mobility and ... It is an agonist of PPARα and is a peroxisome proliferator in rodents contributing to a well understood form of oxidative stress. [120]
Peroxisomal disorders represent a class of medical conditions caused by defects in peroxisome functions. [1] This may be due to defects in single enzymes [2] important for peroxisome function or in peroxins, proteins encoded by PEX genes that are critical for normal peroxisome assembly and biogenesis.
Both parents will have to have the recessive gene for the child to show symptoms. If one parent has the gene and the other one does not, the child will be a carrier and will not show symptoms. Any mutation involving the genes that create or work the peroxisomes can lead to the development of any of the Zellweger Spectrum Disorders.
The peroxisome is an organelle in the cell similar to the lysosome that functions to detoxify the cell. Peroxisomes contain many different enzymes, such as catalase, and their main function is to neutralize free radicals and detoxify drugs. For this reason peroxisomes are ubiquitous in the liver and kidney.
Pirinixic acid is a peroxisome proliferator-activated receptor alpha (PPARα) agonist that is under experimental investigation for prevention of severe cardiac dysfunction, cardiomyopathy and heart failure as a result of lipid accumulation within cardiac myocytes. [1]
Peroxisome is an organelle in all animal and many plant cells that carries out oxidation reactions, some of which produce the toxic compound hydrogen peroxide (H2O2). Peroxisomes contain the enzyme catalase, which catalyzes the breakdown of toxic H2O2 to water and O2. This was created as a seperate article based on a misspelling of the title.