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Severe sepsis causes poor organ function or blood flow. [9] The presence of low blood pressure, high blood lactate, or low urine output may suggest poor blood flow. [9] Septic shock is low blood pressure due to sepsis that does not improve after fluid replacement. [9] Sepsis is caused by many organisms including bacteria, viruses, and fungi. [10]
According to current guidelines, requirements for diagnosis with sepsis are "the presence (probable or documented) of infection together with systemic manifestations of infection". [9] These manifestations may include: Tachypnea (fast rate of breathing), which is defined as more than 20 breaths per minute, or when testing blood gas, a PaCO
Distributive shock is a medical condition in which abnormal distribution of blood flow in the smallest blood vessels results in inadequate supply of blood to the body's tissues and organs. [ 1 ] [ 2 ] It is one of four categories of shock , a condition where there is not enough oxygen -carrying blood to meet the metabolic needs of the cells ...
Acid-base disturbances such as lactic acidosis are typically first assessed using arterial blood gas tests. Testing of venous blood is also available as an alternative as they are effectively interchangeable. [3] Normally resulting lactate concentrations are in the range indicated below: [16]
Wet gangrene usually develops rapidly due to blockage of venous (mainly) or arterial blood flow. [15] The affected part is saturated with stagnant blood, which promotes the rapid growth of bacteria. The toxic products formed by bacteria are absorbed, causing systemic manifestation of sepsis and finally death.
Venous blood is typically colder than arterial blood, [1] and has a lower oxygen content and pH. It also has lower concentrations of glucose and other nutrients and has higher concentrations of urea and other waste products. The difference in the oxygen content of arterial blood and venous blood is known as the arteriovenous oxygen difference.
Except during hypothermia and in severe sepsis, low mixed venous oxygen saturations are indication of inadequate hemodynamics. The ability of the pulmonary artery catheter to sample mixed venous blood is of great utility to manage low cardiac output states.
A blood gas test or blood gas analysis tests blood to measure blood gas tension values and blood pH.It also measures the level and base excess of bicarbonate.The source of the blood is reflected in the name of each test; arterial blood gases come from arteries, venous blood gases come from veins and capillary blood gases come from capillaries. [1]