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Bone is broken down by osteoclasts, and rebuilt by osteoblasts, both of which communicate through cytokine (TGF-β, IGF) signalling. Ossification (also called osteogenesis or bone mineralization) in bone remodeling is the process of laying down new bone material by cells named osteoblasts. It is synonymous with bone tissue formation. [1]
All hard materials in animals are achieved by the biomineralization process - dedicated cells deposit minerals to a soft polymeric (protein) matrix to strengthen, harden and/or stiffen it. Thus, biomimetic mineralization is an obvious and effective process for building synthetic materials with superior mechanical properties.
As you get older, your bones don't make new bone fast enough to keep up with your body's needs. The calcium taken from your bones causes you to lose bone density. Bone loss also speeds up after ...
One of the principal causes of arterial stiffening with age is vascular calcification. Vascular calcification is the deposition of mineral in the form of calcium phosphate salts in the smooth muscle-rich medial layer of large arteries including the aorta. DNA damage, especially oxidative DNA damage, causes accelerated vascular calcification. [11]
Bone tissue is a dynamic system with active metabolism. [24] Bone tissue remodelling or bone remodeling is a successive chain of old bone matrix removal and its replacement with a new one. [25] These processes make a child’s skeleton grow and extend, while childhood is characterized by bone tissue growth rather than its resorption.
Bone tissue is removed by osteoclasts, and then new bone tissue is formed by osteoblasts. Both processes utilize cytokine (TGF-β, IGF) signalling.In osteology, bone remodeling or bone metabolism is a lifelong process where mature bone tissue is removed from the skeleton (a process called bone resorption) and new bone tissue is formed (a process called ossification or new bone formation).
The mechanism of mineral formation in bone is clearly distinct from the phylogenetically older process by which cartilage is mineralized: tetracycline does not label mineralized cartilage at narrow bands or in specific sites, but diffusely, in keeping with a passive mineralization mechanism.
Mineralization may refer to: Biomineralization (mineralization in biology), when an inorganic substance precipitates in an organic matrix Mineralized tissues are tissues that have undergone mineralization, including bones, teeth, antlers, and marine shells Bone remodeling, involving demineralization and remineralization in bones