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A nicotine lozenge is a modified-release dosage tablet (usually flavored) that contains a dose of nicotine polacrilex, which dissolves slowly in the mouth to release nicotine over the course of 20 to 30 minutes. Nicotine lozenges are intended to help individuals quit smoking and are generally an over-the-counter medication.
Nicotine polacrilex is nicotine bound to an ion-exchange resin (polymethacrylic acid, such as Amberlite IRP64, Purolite C115HMR or Doshion P551). [4] It is added to gum and hard lozenges used for nicotine replacement therapy in smoking cessation , such as in the Nicorette range of products.
The LD 50 of nicotine is 50 mg/kg for rats and 3 mg/kg for mice. 0.5–1.0 mg/kg can be a lethal dosage for adult humans, and 0.1 mg/kg for children. [19] [20] However the widely used human LD 50 estimate of 0.5–1.0 mg/kg was questioned in a 2013 review, in light of several documented cases of humans surviving much higher doses; the 2013 review suggests that the lower limit causing fatal ...
Side effects are similar to those from nicotine in general and oral nicotine products, Hrywna says. “Issues like nausea, elevated heart rate, and mouth irritation could also occur with a product ...
A new review of existing studies pinpoints the most effective strategies that can help a person quit smoking. These include a common anti-nicotine drug, a plant-based drug, and nicotine e-cigarettes.
Nicorette is the brand name of a number of products for nicotine replacement therapy (NRT) that contain nicotine polacrilex. Developed in the late 1970s in Sweden by AB Leo [ sv ] in the form of a chewing gum, Nicorette was the first nicotine replacement product on the market.
Nicotine lozenges deliver doses as low as 1 mg up to 4 mg. It is not chewed as the gum would be, and dissolves in approximately 30 minutes. [33] This formulation may be preferred by those individuals who do not find gum chewing to be acceptable. Nicotine gum is available in doses of 2 mg and 4 mg.
There's a ton of sugar [in lozenges]." Related: Josh Brolin recalls the time his mother nearly fed someone to a lion: 'She was absolutely f---ing nuts' Jeff Spicer/Getty
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