Search results
Results from the WOW.Com Content Network
Binding of calcium ion to this domain increases the affinity of MYLK binding to myosin light chain. This myosin binding domain is located at the C-Terminus end of the kinase. On the other side of the kinase at the N-Terminus end, sits the actin-binding domain, which allows MYLK to form interactions with actin filaments, keeping it in place. [4] [5]
Myosin light chain kinase (MLCK) inhibitors are one of the few peptides that can cross the plasma membrane relatively quickly. Under stressful conditions, MLCK's in the human body promotes increased permeability of microvessels. It is thought that MLCK phosphorylates endothelial myosin, leading to cell contraction.
This gene, a muscle member of the immunoglobulin superfamily, encodes a myosin light-chain kinase, which is a calcium-/calmodulin-dependent enzyme.This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity.
228785 Ensembl ENSG00000101306 ENSMUSG00000027470 UniProt Q9H1R3 Q8VCR8 RefSeq (mRNA) NM_033118 NM_001081044 RefSeq (protein) NP_149109 NP_001074513 Location (UCSC) Chr 20: 31.82 – 31.83 Mb Chr 2: 152.75 – 152.76 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Myosin light chain kinase 2 also known as MYLK2 is an enzyme which in humans is encoded by the MYLK2 gene. Function This ...
Telokin's systematic name is ATP:[myosin light chain] O-phosphotransferase and its recommended name is myosin-light-chain kinase. (EC 2.7.11.18). The gene MYLK, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. Four transcript variants that produce four ...
213435 Ensembl ENSG00000140795 ENSMUSG00000031698 UniProt Q32MK0 Q3UIZ8 RefSeq (mRNA) NM_001308301 NM_182493 NM_001297612 NM_175441 RefSeq (protein) NP_001295230 NP_872299 NP_001284541 NP_780650 Location (UCSC) Chr 16: 46.7 – 46.79 Mb Chr 8: 86.05 – 86.11 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Myosin light chain kinase 3 also known as MYLK3, is an enzyme which in humans ...
Myosin light-chain phosphatase, also called myosin phosphatase (EC 3.1.3.53; systematic name [myosin-light-chain]-phosphate phosphohydrolase), is an enzyme (specifically a serine/threonine-specific protein phosphatase) that dephosphorylates the regulatory light chain of myosin II: [myosin light-chain] phosphate + H 2 O = [myosin light-chain ...
In smooth muscle, a single gene [20]) codes for the heavy chains myosin II, but splice variants of this gene result in four distinct isoforms. [19] It also contains 4 myosin light chains (MLC), resulting in 2 per head, weighing 20 (MLC 20) and 17 (MLC 17) kDa. [19] These bind the heavy chains in the "neck" region between the head and tail.