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Cryptococcus neoformans is an encapsulated basidiomycetous yeast [1] belonging to the class Tremellomycetes and an obligate aerobe [2] that can live in both plants and animals. . Its teleomorph is a filamentous fungus, formerly referred to Filobasidiella neoform
It may also infect organ-transplant recipients and people receiving certain cancer treatments. [9] In its yeast state C. neoformans is found in the droppings of wild birds, often pigeons; when dust of the droppings is stirred up, it can infect humans or pets
Cryptococcus gattii, formerly known as Cryptococcus neoformans var. gattii, is an encapsulated yeast found primarily in tropical and subtropical climates. Its teleomorph is Filobasidiella bacillispora , a filamentous fungus belonging to the class Tremellomycetes .
Cryptococcosis is a potentially fatal fungal infection of mainly the lungs, presenting as a pneumonia, and in the brain, where it appears as a meningitis. [4] [9] [12] Coughing, difficulty breathing, chest pain and fever are seen when the lungs are infected. [5]
The genus Filobasidiella forms basidia on hyphae but the main infectious stage is more commonly known by the anamorphic yeast name Cryptococcus, e.g. Cryptococcus neoformans [19] and Cryptococcus gattii. [18] The dimorphic Basidiomycota with yeast stages and the pleiomorphic rusts are examples of fungi with anamorphs, which are the asexual ...
Cryptococcus neoformans is a basidiomycetous fungus that grows as a budding yeast in culture and infected hosts. C. neoformans causes life-threatening meningoencephalitis in immunocompromised patients. It undergoes a filamentous transition during the sexual cycle to produce spores, the suspected infectious agent.
C. neoformans is the most common pathogen to cause fungal meningitis. Aspergillus - Aspergillus infections account for 5% of fungal infections involving the central nervous system. Risk factors
Infecting C. neoformans cells are usually phagocytosed by alveolar macrophages in the lung. [11] The invading C. neoformans cells may be killed by the release of oxidative and nitrosative molecules by these macrophages. [12] However some C. neoformans cells may survive within the macrophages. [11]
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