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16363 Ensembl ENSG00000168310 ENSMUSG00000031627 UniProt P14316 P23906 RefSeq (mRNA) NM_002199 NM_008391 RefSeq (protein) NP_002190 NP_032417 Location (UCSC) Chr 4: 184.39 – 184.47 Mb Chr 8: 47.19 – 47.3 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interferon regulatory factor 2 is a protein that in humans is encoded by the IRF2 gene. Function IRF2 encodes interferon ...
Interferon regulatory factors (IRF) are proteins which regulate transcription of interferons (see regulation of gene expression). [1] Interferon regulatory factors contain a conserved N-terminal region of about 120 amino acids, which folds into a structure that binds specifically to the IRF-element (IRF-E) motifs, which is located upstream of the interferon genes. [2]
Interferon regulatory factor 5 is a protein that in humans is encoded by the IRF5 gene. [5] The IRF family is a group of transcription factors that are involved in signaling for virus responses in mammals along with regulation of certain cellular functions.
The function of IRF6 is related to the formation of connective tissue, for example that of the palate. [7] This gene encodes a member of the interferon regulatory transcription factor (IRF) family. In addition, it has been observed that IRF6 gene is under epigenetic regulation by promoter methylation .
IRF4 is a transcription factor belonging to the Interferon Regulatory Factor (IRF) family of transcription factors. [8] [9] In contrast to some other IRF family members, IRF4 expression is not initiated by interferons; rather, IRF4 expression is promoted by a variety of bioactive stimuli, including antigen receptor engagement, lipopolysaccharide (LPS), IL-4, and CD40.
IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including the type I interferon genes. In particular, IRF7 regulates many interferon-alpha genes. [5]
270110 Ensembl ENSG00000168264 ENSMUSG00000051495 UniProt Q7Z5L9 E9Q1P8 RefSeq (mRNA) NM_182972 NM_001077397 NM_001164598 RefSeq (protein) NP_001070865 NP_892017 NP_001158070 Location (UCSC) Chr 1: 234.6 – 234.61 Mb Chr 8: 127.32 – 127.32 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interferon regulatory factor 2 binding protein 2 is a protein that in humans is encoded by the ...
IRF3 is a member of the interferon regulatory transcription factor (IRF) family. [5] IRF3 was originally discovered as a homolog of IRF1 and IRF2.IRF3 has been further characterized and shown to contain several functional domains including a nuclear export signal, a DNA-binding domain, a C-terminal IRF association domain and several regulatory phosphorylation sites. [6]