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  2. Carcinogenesis - Wikipedia

    en.wikipedia.org/wiki/Carcinogenesis

    Development of cancer was proposed in 1971 to depend on at least two mutational events. In what became known as the Knudson two-hit hypothesis, an inherited, germ-line mutation in a tumor suppressor gene would cause cancer only if another mutation event occurred later in the organism's life, inactivating the other allele of that tumor ...

  3. Causes of cancer - Wikipedia

    en.wikipedia.org/wiki/Causes_of_cancer

    A cancer syndrome or family cancer syndrome is a genetic disorder in which inherited genetic mutations in one or more genes predisposes the affected individuals to the development of cancers and may also cause the early onset of these cancers. Although cancer syndromes exhibit an increased risk of cancer, the risk varies.

  4. Genotoxicity - Wikipedia

    en.wikipedia.org/wiki/Genotoxicity

    The compromised integrity of the genetic material has been known to cause cancer. As a consequence, many sophisticated techniques including Ames Assay, in vitro and in vivo Toxicology Tests, and Comet Assay have been developed to assess the chemicals' potential to cause DNA damage that may lead to cancer.

  5. Malignant transformation - Wikipedia

    en.wikipedia.org/wiki/Malignant_transformation

    One underlying commonality in cancers is genetic mutation, acquired either by inheritance, or, more commonly, by mutations in one's somatic DNA over time. The mutations considered important in cancers are those that alter protein coding genes (the exome). As Vogelstein et al. point out, a typical tumor contains two to eight exome "driver gene ...

  6. Warburg hypothesis - Wikipedia

    en.wikipedia.org/wiki/Warburg_hypothesis

    Scientist Otto Warburg, whose research activities led to the formulation of the Warburg hypothesis for explaining the root cause of cancer.. The Warburg hypothesis (/ ˈ v ɑːr b ʊər ɡ /), sometimes known as the Warburg theory of cancer, postulates that the driver of carcinogenesis (cancer formation) is insufficient cellular respiration caused by insult (damage) to mitochondria. [1]

  7. Caramel Coloring in Coca-Cola, Pepsi Causes Cancer, Group Says

    www.aol.com/news/2011-02-16-caramel-coloring-in...

    The Center for Science in the Public Interest today called on the U.S. Food and Drug Administration to ban the use of certain caramel coloring in foods and sodas including Coca-Cola and Pepsi ...

  8. Mutagen - Wikipedia

    en.wikipedia.org/wiki/Mutagen

    Other carcinogens may cause cancer through a variety of mechanisms without producing mutations, such as tumour promotion, immunosuppression that reduces the ability to fight cancer cells or pathogens that can cause cancer, disruption of the endocrine system (e.g. in breast cancer), tissue-specific toxicity, and inflammation (e.g. in colorectal ...

  9. Seed Oil: Study Links Omega-6s to Colon Cancer—What’s the ...

    www.aol.com/seed-oil-study-links-omega-113000729...

    New research links omega-6 fatty acids, commonly found in seed oils, and colon cancer growth. But there’s more to the story—and study if you read it carefully.