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HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family. But contrary to other members of the ERBB family, HER2 does not directly bind ligand. HER2 activation results from heterodimerization with another ERBB member or by homodimerization when HER2 concentration are high, for instance in cancer. [8]
Clinical trial phase II results reported for brigatinib targeting the T790M mutation, and brigatinib received Breakthrough Therapy designation status by FDA in Feb. 2015. The most common adverse effect of EGFR inhibitors, found in more than 90% of patients, is a papulopustular rash that spreads across the face and torso; the rash's presence is ...
In cell biology, there are a multitude of signalling pathways. Cell signalling is part of the molecular biology system that controls and coordinates the actions of cells.
The HER2 pathway promotes cell growth and division when it is functioning normally; however, when it is overexpressed, cell growth accelerates beyond its normal limits. In some types of cancer, the pathway is exploited to promote rapid cell growth and proliferation and hence tumor formation. [59]
A Wheel of Fortune contestant has gone viral for her "cheesesteak" blunder.. On the Monday, Dec. 30 episode, Gaelyn Nease from Tallahassee, Florida, appeared to be poised to win big as she faced ...
The pathway communicates information from chemical signals outside of a cell to the cell nucleus, resulting in the activation of genes through the process of transcription. There are three key parts of JAK-STAT signalling: Janus kinases (JAKs), signal transducer and activator of transcription proteins (STATs), and receptors (which bind the ...
This held true even after adjusting for age, sex, education level, BMI, ApoE carrier status, blood pressure, diabetes and hyperlipidemia (high cholesterol and blood fats). Results were similar for ...
“Archangel” by Olly Alexander (Years & Years) “When I first heard ‘Archangel’ by Olly Alexander, I felt an bolt of serotonin creep into my bloodstream.
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