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Anti-Saccharomyces cerevisiae antibodies (ASCAs) are antibodies against antigens presented by the cell wall of the yeast Saccharomyces cerevisiae. These antibodies are directed against oligomannose sequences α-1,3 Man (α-1,2 Man α-1,2 Man) n (n = 1 or 2). [ 1 ]
Symptoms can range from mild to extreme—often described as extreme flu-like symptoms. Many symptoms may be associated with fungemia, including pain, acute confusion, chronic fatigue, and infections. Skin infections can include persistent or non-healing wounds and lesions, sweating, itching, and unusual discharge or drainage. [citation needed]
Antibodies against S. cerevisiae are found in 60–70% of patients with Crohn's disease and 10–15% of patients with ulcerative colitis, and may be useful as part of a panel of serological markers in differentiating between inflammatory bowel diseases (e.g. between ulcerative colitis and Crohn's disease), their localization and severity.
Saccharomycetes belongs to the Ascomycota division of the kingdom Fungi.It is the only class in the subdivision Saccharomycotina, the budding yeasts.Saccharomycetes contains a single order, Saccharomycetales.
Saccharomycotina is a subdivision (subphylum) of the division (phylum) Ascomycota in the kingdom Fungi. [2] [3] It comprises most of the ascomycete yeasts.The members of Saccharomycotina reproduce by budding and they do not produce ascocarps (fruiting bodies).
The Crabtree effect, named after the English biochemist Herbert Grace Crabtree, [1] describes the phenomenon whereby the yeast, Saccharomyces cerevisiae, produces ethanol (alcohol) in aerobic conditions at high external glucose concentrations rather than producing biomass via the tricarboxylic acid (TCA) cycle, the usual process occurring aerobically in most yeasts e.g. Kluyveromyces spp. [2 ...
A subunit vaccine is a vaccine that contains purified parts of the pathogen that are antigenic, or necessary to elicit a protective immune response. [1] [2] Subunit vaccine can be made from dissembled viral particles in cell culture or recombinant DNA expression, [3] in which case it is a recombinant subunit vaccine.
A vaccine adverse event (VAE), sometimes referred to as a vaccine injury, is an adverse event believed to have been caused by vaccination. [1] The World Health Organization (WHO) refers to Adverse Events Following Immunization ( AEFI ).