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  2. Spanish flu - Wikipedia

    en.wikipedia.org/wiki/Spanish_flu

    A 2009 study in Influenza and Other Respiratory Viruses based on data from fourteen European countries estimated a total of 2.64 million excess deaths in Europe attributable to the Spanish flu during the major 1918–1919 phase of the pandemic, in line with the three prior studies from 1991, 2002, and 2006 that calculated a European death toll ...

  3. MERS outbreak - Wikipedia

    en.wikipedia.org/wiki/MERS_outbreak

    With this announcement, the unofficial global case count reached 49 while the death toll stood at 24 according to the CDC. [55] As of 26 June 34 deaths have been recorded in the kingdom. [21] On 1 August 2013, the World Health Organization announced three new MERS-CoV cases in that Saudi Arabia, all of them in women, two of whom were healthcare ...

  4. Human mortality from H5N1 - Wikipedia

    en.wikipedia.org/wiki/Human_mortality_from_H5N1

    This single amino acid change in the NS1 gene greatly increased the pathogenicity of the H5N1 influenza virus. This is one genetic factor in why H5N1 is so deadly. [citation needed] Polymerase encoding gene segments are also implicated in why H5N1 is so deadly. PA genes code for the PA protein, which is a critical component of the viral polymerase.

  5. The 9 Worst Years in History to be Alive - AOL

    www.aol.com/9-worst-years-history-alive...

    The Spanish Flu, the second deadliest pandemic in history after the bubonic plague, along with the aftermath of World War I and ensuing political and social chaos, made 1918 a tough time to be alive.

  6. Case fatality rate - Wikipedia

    en.wikipedia.org/wiki/Case_fatality_rate

    The CFR for the Spanish (1918) flu was greater than 2.5%, while the Asian (1957-58) and Hong Kong (1968-69) flus both had a CFR of about 0.2%. [ 11 ] [ 12 ] [ 13 ] As of 13 Jan 2025, coronavirus disease 2019 has an overall CFR of 0.91%, although the CFRs of earlier strains of COVID-19 was around 2%, the CFRs for original SARS and MERS are about ...

  7. Influenza A vs. Influenza B: Which Flu Virus Is Worse? - AOL

    www.aol.com/influenza-vs-influenza-b-flu...

    That is exactly what happened with the 2009 H1N1 swine flu and the Spanish flu of 1918 pandemics. Influenza A subtypes. Influenza A (but not B) also has subtypes labeled H and N. These refer to ...

  8. Influenza A virus subtype H1N1 - Wikipedia

    en.wikipedia.org/wiki/Influenza_A_virus_subtype_H1N1

    The 1918 flu caused an abnormally high number of deaths, possibly due to it provoking a cytokine storm in the body. [ 14 ] [ 15 ] (The H5N1 bird flu , also an Influenza A virus, has a similar effect.) [ 16 ] After the 1918 flu infected lung cells, it frequently led to overstimulation of the immune system via release of immune response ...

  9. How deadly is bird flu in humans? What we know as US ... - AOL

    www.aol.com/news/deadly-bird-flu-humans-know...

    Amid an ongoing outbreak of bird flu among poultry and dairy cows, the United States has recorded its first human death due the virus known as avian influenza A or H5N1. The Louisiana patient died ...