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Wolfram syndrome, also called DIDMOAD (diabetes insipidus, diabetes mellitus, optic atrophy, and deafness), is a rare autosomal-recessive genetic disorder that causes childhood-onset diabetes mellitus, optic atrophy, and deafness as well as various other possible disorders including neurodegeneration.
Diabetes insipidus (DI) is a condition characterized by large amounts of dilute urine and increased thirst. [1] The amount of urine produced can be nearly 20 liters per day. [ 1 ] Reduction of fluid has little effect on the concentration of the urine. [ 1 ]
In severe or acute hypoosmolar hyponatremia, swelling of brain cells causes various neurological abnormalities, which in severe or acute cases can result in convulsions, coma, and death. The symptoms of chronic syndrome of inappropriate antidiuresis are more vague, and may include cognitive impairment , gait abnormalities , or osteoporosis .
As a diagnosis of exclusion, a diagnosis of primary polydipsia may be the result of elimination of the possibility of diseases causing similar signs and symptoms, such as diabetes insipidus. [ 12 ] Diagnosis may be complicated by the fact that chronic and extreme compulsive drinking may impair the response of the kidneys to vasopressin , thus ...
Polydipsia can be characteristic of diabetes mellitus, often as an initial symptom. It is observed in cases of poorly controlled diabetes, which is sometimes the result of low patient adherence to anti-diabetic medication. [1] Diabetes insipidus ("tasteless" diabetes, as opposed to diabetes mellitus) can also cause polydipsia. [1]
For people who want to try out intermittent fasting, "it is advisable to start gradually, listen carefully to your body, and pay attention if you start feeling unwell," suggests Bracamonte.
Federal pardons issued by the president apply only to federal offenses; they do not apply to state or local offenses or to private civil lawsuits. [40] Pardons for state crimes are handled by governors or a state pardon board. [1] The president's power to grant pardons explicitly does not apply "in cases of impeachment." This means that the ...
"The president can pardon as many people or as few people as you would like. He can do it at any time he would like." As Hunter Biden pardon sparks backlash, experts say it can't be overturned ...