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2. Discovery and development of angiotensin receptor blockers

   en.wikipedia.org/wiki/Discovery_and_development...

   Losartan, valsartan, candesartan, irbesartan, telmisartan and olmesartan all contain a biphenyl-methyl group. Losartan is partly metabolized to its 5- carboxylic acid metabolite EXP 3174, which is a more potent AT 1 receptor antagonist than its parent compound [ 17 ] and has been a model for the continuing development of several other ARBs.

3. Valsartan - Wikipedia

   en.wikipedia.org/wiki/Valsartan

   Valsartan, sold under the brand name Diovan among others, is a medication used to treat high blood pressure, heart failure, and diabetic kidney disease. [8] It belongs to a class of medications referred to as angiotensin II receptor blockers (ARBs).

4. Angiotensin II receptor blocker - Wikipedia

   en.wikipedia.org/wiki/Angiotensin_II_receptor...

   Losartan, the first ARB. Angiotensin II receptor blockers (ARBs), formally angiotensin II receptor type 1 (AT 1) antagonists, [1] also known as angiotensin receptor blockers, [2] [3] angiotensin II receptor antagonists, or AT 1 receptor antagonists, are a group of pharmaceuticals that bind to and inhibit the angiotensin II receptor type 1 (AT 1) and thereby block the arteriolar contraction and ...

5. List of cardiac pharmaceutical agents - Wikipedia

   en.wikipedia.org/wiki/List_of_cardiac...

   Valsartan; Beta blocker. Class of medications that are competitive antagonists that block the receptor sites for the endogenous catecholamines epinephrine (adrenaline ...

6. How much does Entresto cost with Medicare? - AOL

   www.aol.com/much-does-entresto-cost-medicare...

   Sacubitril-valsartan (Entresto) is the first medication with Food and Drug Administration (FDA) approval in a class of drugs called angiotensin receptor neprilysin inhibitors (ARNIs). It is only ...

7. Cardiovascular agents - Wikipedia

   en.wikipedia.org/wiki/Cardiovascular_agents

   Antihypertensive agents comprise multiple classes of compounds that are intended to manage hypertension (high blood pressure). Antihypertensive therapy aims to maintain a blood pressure goal of <140/90 mmHg in all patients, as well as to prevent the progression or recurrence of cardiovascular diseases (CVD) in hypertensive patients with established CVD. [2]

8. Antihypertensive - Wikipedia

   en.wikipedia.org/wiki/Antihypertensive

   The CHARM-alternative trial showed a significant +52% (p=0.025) increase in myocardial infarction with candesartan (versus placebo) despite a reduction in blood pressure. [26] As a consequence of AT1 blockade, ARBs increase angiotensin II levels several-fold above baseline by uncoupling a negative-feedback loop. Increased levels of circulating ...

9. AOL Mail

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   Get AOL Mail for FREE! Manage your email like never before with travel, photo & document views. Personalize your inbox with themes & tabs. You've Got Mail!