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Low energy levels and stress: The AMP-dependent protein kinase AMPK phosphorylates and thereby activates TSC1-TSC2 by phosphorylating at least 2 residues of TSC2. [7] Hypoxia: The Hypoxia-inducible factor α HIFα induces REDD1 at low oxygen levels. REDD1 has been shown to activate TSC1-TSC2 by neutralisation of AKT dependent inhibition. [8]
Pharmacological inhibition of ERK1/2 restores GSK3β activity and protein synthesis levels in a model of tuberous sclerosis. [8]The defective degradation of glycogen by the autophagy-lysosome pathway is, at least in part, independent of impaired regulation of mTORC1 and is restored by the combined use of PKB/Akt and mTORC1 pharmacological inhibitors.
Tuberous sclerosis complex (TSC) is a rare multisystem autosomal dominant genetic disease that causes non-cancerous tumours to grow in the brain and on other vital organs such as the kidneys, heart, liver, eyes, lungs and skin.
TSC1 functions as a co-chaperone which inhibits the ATPase activity of the chaperone Hsp90 (heat shock protein-90) and decelerates its chaperone cycle. TSC1 functions as a facilitator of Hsp90 in chaperoning the kinase and non-kinase clients including TSC2, therefore preventing their ubiquitination and degradation in the proteasome. [6]
Minit is an action-adventure video game developed by Jan Willem Nijman, Kitty Calis, Jukio Kallio, and Dominik Johann.The game is published by Devolver Digital and was released on April 3, 2018, for Windows, macOS, Linux, Xbox One, and PlayStation 4.
Simone Segouin (French: [simɔn səɡwɛ̃]; 3 October 1925 – 21 February 2023), also known by her nom de guerre Nicole Minet (French: [nikɔl minɛ]), was a French Resistance fighter who served in the Francs-tireurs et partisans group during World War II. Among her first acts of resistance was stealing a bicycle from a German patrol, which ...
The Time Stamp Counter was once a high-resolution, low-overhead way for a program to get CPU timing information. With the advent of multi-core/hyper-threaded CPUs, systems with multiple CPUs, and hibernating operating systems, the TSC cannot be relied upon to provide accurate results — unless great care is taken to correct the possible flaws: rate of tick and whether all cores (processors ...
The city of Sugar Land gave the company a $2.4 million tax incentive to move its headquarters there. [ 28 ] On March 6, 2021, amid the COVID-19 pandemic , Coca-Cola announced it was closing Minute Maid's office in Sugar Land and would join the operations with the company's base in Atlanta, Georgia .