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Structure of a gene regulatory network Control process of a gene regulatory network. A gene (or genetic) regulatory network (GRN) is a collection of molecular regulators that interact with each other and with other substances in the cell to govern the gene expression levels of mRNA and proteins which, in turn, determine the function of the cell.
A gene regulatory network [20] is a set of molecular regulators that interact with each other and with other substances in the cell. The regulator can be DNA, RNA, protein and complexes of these. Gene regulatory networks can be modeled in numerous ways including; Coupled ordinary differential equations, Boolean networks, Continuous networks ...
Procedures to identify association, communities, and centrality within nodes in a biological network can provide insight into the relationships of whatever the nodes represent whether they are genes, species, etc. Formulation of these methods transcends disciplines and relies heavily on graph theory, computer science, and bioinformatics.
Changes in the regulation of gene networks are a common mechanism for prokaryotic evolution.An example of the effects of different regulatory environments for homologous proteins is the DNA-binding protein OmpR, which is involved in response to osmotic stress in E. coli but is involved in response to acidic environments in the close relative Salmonella Typhimurium.
Gene regulatory pathway. In genetics, a regulator gene, regulator, or regulatory gene is a gene involved in controlling the expression of one or more other genes. Regulatory sequences, which encode regulatory genes, are often at the five prime end (5') to the start site of transcription of the gene they regulate. In addition, these sequences ...
Regulation of gene expression, or gene regulation, [1] includes a wide range of mechanisms that are used by cells to increase or decrease the production of specific gene products (protein or RNA). Sophisticated programs of gene expression are widely observed in biology, for example to trigger developmental pathways, respond to environmental ...
Inferring regulatory network: ChIP-seq signal of Histone modification were shown to be more correlated with transcription factor motifs at promoters in comparison to RNA level. [21] Hence author proposed that using histone modification ChIP-seq would provide more reliable inference of gene-regulatory networks in comparison to other methods ...
Wagner's gene network model is a computational model of artificial gene networks, which explicitly modeled the developmental and evolutionary process of genetic regulatory networks. A population with multiple organisms can be created and evolved from generation to generation.