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In the brain, serotonin is a neurotransmitter and regulates arousal, behavior, sleep, and mood, among other things. [9] During prolonged exercise where central nervous system fatigue is present, serotonin levels in the brain are higher than normal physiological conditions; these higher levels can increase perceptions of effort and peripheral muscle fatigue. [9]
The central component of fatigue is triggered by an increase of the level of serotonin in the central nervous system. [133] During motor activity, serotonin released in synapses that contact motor neurons promotes muscle contraction. [134] During high level of motor activity, the amount of serotonin released increases and a spillover occurs.
Central nervous system diseases or central nervous system disorders are a group of neurological disorders that affect the structure or function of the brain or spinal cord, which collectively form the central nervous system (CNS). [1][2][3] These disorders may be caused by such things as infection, injury, blood clots, age related degeneration ...
Some scientists have proposed that damage to this brain region might help explain why some people experience long COVID symptoms, which include: fatigue. brain fog. breathlessness. mental health ...
Fibromyalgia is classed as a disorder of pain processing due to abnormalities in how pain signals are processed in the central nervous system. [36] The International Classification of Diseases (ICD-11) includes fibromyalgia in the category of "Chronic widespread pain," code MG30.01. [37]
As multiple sclerosis (MS) lesions can affect any part of the central nervous system, a person with MS can have almost any neurological symptom or sign referable to the central nervous system. Fatigue is one of the most common symptoms of MS. [26] [27] Some 65% of people with MS experience fatigue symptomatology, and of these, some 15–40% ...
That fatigue and related symptoms can be confused with symptoms of depression and dementia, he says. People with vitamin B12 deficiency may act forgetful and confused, and struggle with ...
Overtraining can be described as a point where a person may have a decrease in performance and plateauing as a result of failure to consistently perform at a certain level or training load; a load which exceeds their recovery capacity. [2] People who are overtrained cease making progress, and can even begin to lose strength and fitness.