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  2. Melarsoprol - Wikipedia

    en.wikipedia.org/wiki/Melarsoprol

    Melarsoprol used for the treatment of African trypanosomiasis with CNS involvement is given under a complicated dosing schedule. The dosing schedule for children and adults is 2–3.6 mg/kg/day intravenously for three days, then repeated every seven days for a total of three series. [6]

  3. Amisulpride - Wikipedia

    en.wikipedia.org/wiki/Amisulpride

    Amisulpride is approved and used at low doses in the treatment of dysthymia and major depressive disorder. [10] [20] [11] [21] [22] [23] Whereas typical doses used in schizophrenia block postsynaptic dopamine D 2-like receptors and reduce dopaminergic neurotransmission, low doses of amisulpride preferentially block presynaptic dopamine D 2 and D 3 autoreceptors and thereby disinhibit dopamine ...

  4. List of investigational autism and pervasive developmental ...

    en.wikipedia.org/wiki/List_of_investigational...

    Blarcamesine (AE-37, ANA001, ANAVEX 2-73) – sigma σ 1, muscarinic acetylcholine M 1, and ionotropic glutamate NMDA receptor agonist [77] Brilaroxazine (RP-5063, RP-5000) – dopamine D 2, D 3, D 4 receptor partial agonist, serotonin 5-HT 1A receptor agonist, serotonin 5-HT 2A, 5-HT 2B, 5-HT 7 receptor antagonist, and atypical antipsychotic [78]

  5. Lofexidine - Wikipedia

    en.wikipedia.org/wiki/Lofexidine

    Lofexidine, sold under the brand name Lucemyra among others, [1] is a medication historically used to treat high blood pressure; today, it is more commonly used to help with the physical symptoms of opioid withdrawal. [2] It is taken by mouth. [3] It is an α 2A-adrenergic receptor agonist. [3]

  6. Daridorexant - Wikipedia

    en.wikipedia.org/wiki/Daridorexant

    Daridorexant is indicated for the treatment of adults with insomnia characterized by difficulties with sleep onset and/or sleep maintenance. [1] The medication has been found to significantly improve latency to persistent sleep (LPS), wake after sleep onset (WASO), and subjective total sleep time (TST) in regulatory clinical trials. [1]

  7. Cornamaddy, WEM Weather - Hourly Forecasts and Local ... - AOL

    www.aol.com/.../westmeath/cornamaddy-91467577

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  8. Hydroxyzine - Wikipedia

    en.wikipedia.org/wiki/Hydroxyzine

    Doses of hydroxyzine hydrochloride used for sleep range from 25 to 100 mg. [15] [16] [17] As with other antihistamine sleep aids, hydroxyzine is usually only prescribed for short term or "as-needed" use since tolerance to the central nervous system (CNS) effects of hydroxyzine can develop in as little as a few days.

  9. Phenibut - Wikipedia

    en.wikipedia.org/wiki/Phenibut

    Phenibut is used in Russia, Ukraine, Belarus and Latvia as a pharmaceutical drug to treat anxiety and to improve sleep (e.g., in the treatment of insomnia). [5] [6] It is also used for various other indications, including the treatment of asthenia, depression, alcoholism, alcohol withdrawal syndrome, post-traumatic stress disorder, stuttering, tics, vestibular disorders, Ménière's disease ...