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  2. Integrin alpha X - Wikipedia

    en.wikipedia.org/wiki/Integrin_alpha_X

    3687 16411 Ensembl ENSG00000140678 ENSMUSG00000030789 UniProt P20702 Q9QXH4 RefSeq (mRNA) NM_000887 NM_001286375 NM_021334 NM_001363984 NM_001363985 RefSeq (protein) NP_000878 NP_001273304 NP_067309 NP_001350913 NP_001350914 Location (UCSC) Chr 16: 31.36 – 31.38 Mb Chr 7: 127.73 – 127.75 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse CD11c, also known as Integrin, alpha X ...

  3. Nude mouse - Wikipedia

    en.wikipedia.org/wiki/Nude_mouse

    A nude mouse is a laboratory mouse from a strain with a genetic mutation that causes a deteriorated or absent thymus, resulting in an inhibited immune system due to a greatly reduced number of T cells. The phenotype (main outward appearance) of the mouse is a lack of body hair, which gives it the "nude" nickname.

  4. Knockout mouse - Wikipedia

    en.wikipedia.org/wiki/Knockout_mouse

    There are several thousand different strains of knockout mice. [3] Many mouse models are named after the gene that has been inactivated. For example, the p53 knockout mouse is named after the p53 gene which codes for a protein that normally suppresses the growth of tumours by arresting cell division and/or inducing apoptosis.

  5. International Knockout Mouse Consortium - Wikipedia

    en.wikipedia.org/wiki/International_Knockout...

    The consortium encompasses four major, high-throughput gene-targeted mutagenesis programs: the National Institutes of Health (NIH)-sponsored Knockout Mouse Program (KOMP) and state-funded Texas Institute for Genomic Medicine (TIGM) in the U.S., the North American Conditional Mouse Mutagenesis (NorCOMM) Program in Canada, and the European ...

  6. International Mouse Phenotyping Consortium - Wikipedia

    en.wikipedia.org/wiki/International_Mouse_Pheno...

    The International Mouse Phenotyping Consortium (IMPC) is an international scientific endeavour to create and characterize the phenotype of 20,000 knockout mouse strains. [1] [2] [3] Launched in September 2011, [1] the consortium consists of over 15 research institutes across four continents with funding provided by the NIH, European national governments and the partner institutions.

  7. Backcrossing - Wikipedia

    en.wikipedia.org/wiki/Backcrossing

    As the figure shows, each time that the mouse with the desired trait (in this case the lack of a gene (i.e. a knockout), indicated by the presence of a positive selectable marker) is crossed with a mouse of a constant genetic background, the average percentage of the genetic material of the offspring that is derived from that constant ...

  8. Genetically modified mouse - Wikipedia

    en.wikipedia.org/wiki/Genetically_modified_mouse

    The genetically modified mouse in which a gene affecting hair growth has been knocked out (left) shown next to a normal lab mouse. A genetically modified mouse, genetically engineered mouse model (GEMM) [1] or transgenic mouse is a mouse (Mus musculus) that has had its genome altered through the use of genetic engineering techniques.

  9. Genetically modified mammal - Wikipedia

    en.wikipedia.org/wiki/Genetically_modified_mammal

    Genetically modified mammals are mammals that have been genetically engineered.They are an important category of genetically modified organisms.The majority of research involving genetically modified mammals involves mice with attempts to produce knockout animals in other mammalian species limited by the inability to derive and stably culture embryonic stem cells.

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