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HPLC has many applications in both laboratory and clinical science. It is a common technique used in pharmaceutical development, as it is a dependable way to obtain and ensure product purity. [59] While HPLC can produce extremely high quality (pure) products, it is not always the primary method used in the production of bulk drug materials. [60]
The spot capacity (analogous to peak capacity in HPLC) can be increased by developing the plate with two different solvents, using two-dimensional chromatography. [8] The procedure begins with development of a sample loaded plate with first solvent. After removing it, the plate is rotated 90° and developed with a second solvent.
Collaboration is a critical factor in the equipment supply chain. [2] Equipment companies must have two fundamentals in place of operational control of service operations on the one hand and equipment intelligence on the other. (1) This enables companies to move to proactive service approaches and make better business decisions.
The interface between a liquid phase technique (HPLC) with a continuously flowing eluate, and a gas phase technique carried out in a vacuum was difficult for a long time. The advent of electrospray ionization changed this. Currently, the most common LC–MS interfaces are electrospray ionization (ESI), atmospheric pressure chemical ionization ...
Waters Corporation is an American publicly traded analytical laboratory instrument and software company headquartered in Milford, Massachusetts.The company employs more than 7,800 [2] people, with manufacturing facilities located in Milford, Taunton, Massachusetts; Wexford, Ireland and Wilmslow, [3] Cheshire.
Silica gel particles are commonly used as a stationary phase in high-performance liquid chromatography (HPLC) for several reasons, [13] [14] including: High surface area: Silica gel particles have a high surface area, allowing direct interactions with solutes or after bonding of variety of ligands for versatile interactions with the sample molecules, leading to better separations.
The charged aerosol detector (CAD) is a detector used in conjunction with high-performance liquid chromatography (HPLC) and ultra high-performance liquid chromatography (UHPLC) to measure the amount of chemicals in a sample by creating charged aerosol particles which are detected using an electrometer.
A chromatography detector is a device that detects and quantifies separated compounds as they elute from the chromatographic column.These detectors are integral to various chromatographic techniques, such as gas chromatography, [1] liquid chromatography, and high-performance liquid chromatography, [2] and supercritical fluid chromatography [3] among others.