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In the Patient Zero study, the average length of time between sexual contact and the onset of symptoms was 10 + 1 ⁄ 2 months. [8] While Shilts' book does not make such an allegation, the rumour that Dugas was the principal disseminator of the virus became widespread. [15] In 1988, Andrew R. Moss published an opposing view in The New York ...
Inventing the AIDS Virus is a 1996 book by molecular biologist Peter Duesberg, in which the author argues that HIV does not cause AIDS.Duesberg contends that HIV is a harmless passenger virus and that AIDS is caused by unrelated factors such as drug abuse, antiretroviral medication, chronic malnutrition, poor sanitation, and hemophilia.
The book was published shortly after Willner's medical license was revoked for, among other things, treating an AIDS patient with ozone therapy. [ 2 ] The following month, on October 28, 1994, in a press conference at a Greensboro, North Carolina hotel, Willner jabbed his finger with blood he said was from an HIV-infected patient.
Robert Lee Rayford [1] (February 3, 1953 – May 15, 1969), [2] sometimes identified as Robert R. due to his age, was an American teenager from Missouri who has been suggested to represent the earliest confirmed case of HIV/AIDS in North America. This is based on evidence published in 1988 in which the authors claimed that medical evidence ...
The activation and proliferation of T cells that results from immune activation provides fresh targets for HIV infection. However, direct killing by HIV alone cannot account for the observed depletion of CD4 + T cells since only 0.01–0.10% of CD4 + T cells in the blood are infected. [citation needed]
Duesberg's claim that recreational drug use, rather than HIV, was the cause of AIDS has been specifically examined and found to be false. Cohort studies have found that only HIV-positive drug users develop opportunistic infections; HIV-negative drug users do not develop such infections, indicating that HIV rather than drug use is the cause of AIDS.
Two types of HIV have been characterized: HIV-1 and HIV-2. HIV-1 is the virus that was originally discovered (and initially referred to also as LAV or HTLV-III). It is more virulent, more infective, [99] and is the cause of the majority of HIV infections globally. The lower infectivity of HIV-2 as compared with HIV-1 implies that fewer people ...
Dual-tropic HIV-1 strains are thought to be transitional strains of HIV-1 and thus are able to use both CCR5 and CXCR4 as co-receptors for viral entry. The α-chemokine SDF-1, a ligand for CXCR4, suppresses replication of T-tropic HIV-1 isolates. It does this by down-regulating the expression of CXCR4 on the surface of HIV target cells. M ...