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The extreme endpoint of this distribution are the so-called 'monogenic' obesities where most of the impact on body weight can be tied to a mutation in a single gene that runs in a single family. The classic example of such a genetic effect is the presence of mutations in the leptin gene. [29]
Monogenic obesity is excess weight caused by a mutation in a single gene, as opposed to syndromic obesity not tied to a single gene variation and most obesity, which is caused by multiple genetic and environmental risk factors.
People in the field work toward developing an understanding of how the whole body responds to a food via systems biology, as well as single gene/single food compound relationships. [1] [2] Nutritional genomics or Nutrigenomics is the relation between food and inherited genes, it was first expressed in 2001. [3] [4]
In this context pleiotropy refers to the influence that a specific genetic variant, e.g., a single nucleotide polymorphism or SNP, has on two or more distinct traits. Genome-wide association studies (GWAS) and machine learning analysis of large genomic datasets have led to the construction of SNP based polygenic predictors for human traits such ...
Also called functionalism. The Darwinian view that many or most physiological and behavioral traits of organisms are adaptations that have evolved for specific functions or for specific reasons (as opposed to being byproducts of the evolution of other traits, consequences of biological constraints, or the result of random variation). adaptive radiation The simultaneous or near-simultaneous ...
Monoallelic gene expression (MAE) is the phenomenon of the gene expression, when only one of the two gene copies is actively expressed (transcribed), while the other is silent. [ 1 ] [ 2 ] [ 3 ] Diploid organisms bear two homologous copies of each chromosome (one from each parent), a gene can be expressed from both chromosomes (biallelic ...
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One is based on the gene-model effects, [40] while the other is based on the genotype substitution effects [14] They are algebraically inter-convertible with each other. [36] In this section, the basic random fertilization derivation is considered, with the effects of inbreeding and dispersion set aside. This is dealt with later to arrive at a ...
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