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Finally, CYP1A1 catalyses this intermediate to form BaP-7,8-dihydrodiol-9,10-epoxide, which is a carcinogen. [9] However, an in vivo experiment with gene-deficient mice has found that the hydroxylation of benzo[a]pyrene by CYP1A1 can have an overall protective effect on the DNA, rather than contributing to potentially carcinogenic DNA ...
Induction of CYP1A1 by benzo[a]pyrene occurs via binding to the aryl hydrocarbon receptor in the cytosol, leading the transformed receptor to translocate to the nucleus where it dimerises with aryl hydrocarbon receptor nuclear translocator and then binds xenobiotic response elements in DNA located upstream of certain genes.
Through the action of CYP1A1, CYP1A2, CYP2C8, and the CYP3A isoforms, 16α-hydroxyestradiol (16α-OHE 2), also known as estriol, is produced in abundance during pregnancy. 16α-OHE 2 can be dehydrogenated to 16α-hydroxyestrone (16α-OHE 1), a metabolite that has been shown to bind covalently to the estrogen receptor via Schiff base formation. [11]
The mechanism of action of benzo[a]pyrene-related DNA modification has been investigated extensively and relates to the activity of cytochrome P450 subclass 1A1 . [3] Seemingly, the high activity of CYP1A1 in the intestinal mucosa prevents major amounts of ingested benzo[a]pyrene from entering portal blood and systemic circulation. [4]
Seemingly, CYP1A1 activity in the intestinal mucosa prevents major amounts of ingested benzo[a]pyrene to enter portal blood and systemic circulation. [34] Intestinal, but not hepatic, expression of CYP1A1 depends on TOLL-like receptor 2 ( TLR2 ), [ 35 ] which is a eukaryotic receptor for bacterial surface structures such as lipoteichoic acid .
196 11622 Ensembl ENSG00000106546 ENSMUSG00000019256 UniProt P35869 P30561 RefSeq (mRNA) NM_001621 NM_013464 NM_001314027 RefSeq (protein) NP_001612 NP_001300956 NP_038492 Location (UCSC) Chr 7: 16.92 – 17.35 Mb Chr 12: 35.55 – 35.59 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The aryl hydrocarbon receptor (also known as AhR, AHR, ahr, ahR, AH receptor, or as the dioxin ...
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1544 13077 Ensembl ENSG00000140505 ENSMUSG00000032310 UniProt P05177 P00186 RefSeq (mRNA) NM_000761 NM_009993 RefSeq (protein) NP_000752 NP_034123 Location (UCSC) Chr 15: 74.75 – 74.76 Mb Chr 9: 57.58 – 57.59 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cytochrome P450 1A2 (abbreviated CYP1A2), a member of the cytochrome P450 mixed-function oxidase system, is involved in the ...