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The flavin-containing monooxygenase (FMO) protein family specializes in the oxidation of xeno-substrates in order to facilitate the excretion of these compounds from living organisms. [1] These enzymes can oxidize a wide array of heteroatoms , particularly soft nucleophiles , such as amines , sulfides , and phosphites .
Flavin-containing monooxygenase 3 (FMO3), also known as dimethylaniline monooxygenase [N-oxide-forming] 3 and trimethylamine monooxygenase, is a flavoprotein enzyme (EC 1.14.13.148) that in humans is encoded by the FMO3 gene.
Dimethylaniline monooxygenase [N-oxide-forming] 1 is an enzyme that in humans is encoded by the FMO1 gene. [5]Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in humans resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome ...
Dimethylaniline monooxygenase [N-oxide-forming] 2 is an enzyme that in humans is encoded by the FMO2 gene. [5] [6] [7]The flavin-containing monooxygenases are NADPH-dependent enzymes that catalyze the oxidation of many drugs and xenobiotics.
Trimethylaminuria (TMAU), also known as fish odor syndrome or fish malodor syndrome, [1] is a rare metabolic disorder that causes a defect in the normal production of an enzyme named flavin-containing monooxygenase 3 (FMO3).
Dimethylaniline monooxygenase [N-oxide-forming] 5 is an enzyme in humans encoded by the FMO5 gene. [5] [6] [7]Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome ...
2329 226564 Ensembl ENSG00000076258 ENSMUSG00000026692 UniProt P31512 Q8VHG0 RefSeq (mRNA) NM_002022 NM_144878 RefSeq (protein) NP_002013 NP_659127 Location (UCSC) Chr 1: 171.31 – 171.34 Mb Chr 1: 162.62 – 162.64 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Dimethylaniline monooxygenase [N-oxide-forming] 4 is an enzyme in humans encoded by the FMO4 gene. Function Metabolic N ...
Monooxygenases are enzymes that incorporate one hydroxyl group (−OH) into substrates in many metabolic pathways. In this reaction, the two atoms of dioxygen are reduced to one hydroxyl group and one H 2 O molecule by the concomitant oxidation of NAD(P)H.