Search results
Results from the WOW.Com Content Network
The area provides a reference unit, for example in reference ranges for urine tests. [3]Used for grading of soft tissue tumors: Grading, usually on a scale of I to III, is based on the degree of differentiation, the average number of mitoses per high-power field, cellularity, pleomorphism, and an estimate of the extent of necrosis (presumably a reflection of rate of growth).
The mitotic index is a measure of cellular proliferation. [1] It is defined as the percentage of cells undergoing mitosis in a given population of cells. Mitosis is the division of somatic cells into two daughter cells. Durations of the cell cycle and mitosis vary in different cell types. An elevated mitotic index indicates more cells are dividing.
Mitosis in a neuroendocrine tumor. Mitotic indexing is the oldest method of assessing proliferation and is determined by counting the number of mitotic figures (cells undergoing mitosis) through a light microscope on H&E stained sections. It is usually expressed as the number of cells per microscopic field.
The primary result of mitosis and cytokinesis is the transfer of a parent cell's genome into two daughter cells. The genome is composed of a number of chromosomes—complexes of tightly coiled DNA that contain genetic information vital for proper cell function. [ 32 ]
Note: Mitotic figures are counted only at the periphery of the tumor, and counting should begin in the most mitotically active areas. Mitotic count per 10 high-power fields (HPFs) [ 21 ] Area per HPF
Atypical carcinoid of the lung exhibiting endobronchial growth, increased mitotic activity was seen (2-10 per 10 HPF). H&E stain. Typical pulmonary carcinoid tumor. Typical pulmonary carcinoid lacks comedo-like necrosis, and has < 0.2 mitotic figures/HPF.
Hayflick suggested that his results in which normal cells have a limited replicative capacity may have significance for understanding human aging at the cellular level. [ 4 ] It has been reported that the limited replicative capability of human fibroblasts observed in cell culture is far greater than the number of replication events experienced ...
In hematology, plasma cell dyscrasias (also termed plasma cell disorders and plasma cell proliferative diseases) are a spectrum of progressively more severe monoclonal gammopathies in which a clone or multiple clones of pre-malignant or malignant plasma cells (sometimes in association with lymphoplasmacytoid cells or B lymphocytes) over-produce and secrete into the blood stream a myeloma ...