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Sirtuin 1, also known as NAD-dependent deacetylase sirtuin-1, is a protein that in humans is encoded by the SIRT1 gene. [5] [6] [7]SIRT1 stands for sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae), referring to the fact that its sirtuin homolog (biological equivalent across species) in yeast (Saccharomyces cerevisiae) is Sir2.
In September 2003, Howitz and Sinclair et al. published a highly cited paper reporting that polyphenols such as resveratrol [2] activate human SIRT1 and extend the lifespan of budding yeast (Howitz et al., Nature, 2003).
[2] [3] They are ancient in animal evolution and appear to possess a highly conserved structure throughout all kingdoms of life. [2] Chemically, sirtuins are a class of proteins that possess either mono- ADP-ribosyltransferase or deacylase activity, including deacetylase, desuccinylase , demalonylase , demyristoylase and depalmitoylase activity.
NAD-dependent deacetylase sirtuin 2 is an enzyme that in humans is encoded by the SIRT2 gene. [ 5 ] [ 6 ] [ 7 ] SIRT2 is an NAD+ (nicotinamide adenine dinucleotide)-dependent deacetylase. Studies of this protein have often been divergent, highlighting the dependence of pleiotropic effects of SIRT2 on cellular context.
UniProt Archive (UniParc) is a comprehensive and non-redundant database, which contains all the protein sequences from the main, publicly available protein sequence databases. [17] Proteins may exist in several different source databases, and in multiple copies in the same database.
Newer drives use RPC-2 firmware, which enforces DVD region coding at the hardware level. See DVD region code#Computer DVD drives for further information. Some RPC-2 drives can be converted to RPC-1 with the same features as before by using alternative firmware on the drive, or on some drives by setting a secret flag in the drive's EEPROM .
NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens.
54602 76273 Ensembl ENSG00000102471 ENSMUSG00000053253 UniProt Q9NV92 Q91ZP6 RefSeq (mRNA) NM_001161407 NM_019080 NM_001394685 NM_001190989 NM_029561 RefSeq (protein) NP_001154879 NP_061953 n/a Location (UCSC) Chr 13: 79.48 – 79.56 Mb Chr 14: 105.5 – 105.55 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse NEDD4 family-interacting protein 2 is a protein that in humans is encoded by ...