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Onychorrhexis (from the Greek words ὄνυχο- ónycho-, "nail" and ῥῆξις rhexis, "bursting"), is a brittleness with breakage of finger or toenails that may result from hypothyroidism, anemia, anorexia nervosa or bulimia, or after oral retinoid therapy. [1]: 786 It can also be seen in melanoma that involves the nail and onychomycosis. [2]
When the condition occurs on all the twenty nails of the fingers and toes, it is known as twenty-nail dystrophy, most evident in childhood, [4] favoring males. [ 2 ] [ 5 ] Trachyonychia causes the nails to become opalescent, thin, dull, fragile, and finely longitudinally ridged, and, as a result, distally notched. [ 6 ]
Onychauxis presents with thickened nails without deformity, and this simple thickening may be the result of trauma, acromegaly, Darier's disease, psoriasis, or pityriasis rubra pilaris, or, in some cases, hereditary. [1]: 783 [2] It may appear as loss of nail palate translucency, discoloration, and subungual hyperkeratosis.
Stains of the nail plate (not the nail bed) are associated with smoking and henna use. Splinter hemorrhages (or haemorrhages) are tiny blood clots that tend to run vertically under the nails. Drug-induced nail changes are caused by drug usage which may result in various abnormalities. [6]: 665–6
Muehrcke's lines were described by American physician Robert C. Muehrcke (1921–2003) in 1956. In a study published in BMJ, he examined patients with known chronic hypoalbuminemia and healthy volunteers, finding that the appearance of multiple transverse white lines was a highly specific marker for low serum albumin (no subject with the sign had SA over 2.2 g/dL), was associated with severity ...
"Other nail abnormalities, such as a dark streak or new growth" — which are possible signs of infections or even melanoma — "may also be detected late if you don’t look at unpolished nails ...
Nail psoriasis can affect the fingernails and toenails. It may cause thickening of the nails with areas of pitting, ridges, irregular contour, and even raising of the nail from the nail bed. [16] Squamous-cell carcinoma is mainly cancer of the skin, but can also affect the nail bed. It is a rare malignant subungual tumor subject to misdiagnosis ...
Some secondary Raynaud's patients can experience tissue damage, nail abnormalities, fingertip ulcers or even gangrene that would require amputation, Makol noted. Patients with primary Raynaud’s ...