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  2. Beta-1 adrenergic receptor - Wikipedia

    en.wikipedia.org/wiki/Beta-1_adrenergic_receptor

    The beta-1 adrenergic receptor (β 1 adrenoceptor), also known as ADRB1, can refer to either the protein-encoding gene (gene ADRB1) or one of the four adrenergic receptors. [5] It is a G-protein coupled receptor associated with the Gs heterotrimeric G-protein that is expressed predominantly in cardiac tissue. In addition to cardiac tissue, beta ...

  3. Adrenergic receptor - Wikipedia

    en.wikipedia.org/wiki/Adrenergic_receptor

    The adrenergic receptors or adrenoceptors are a class of G protein-coupled receptors that are targets of many catecholamines like norepinephrine (noradrenaline) and epinephrine (adrenaline) produced by the body, but also many medications like beta blockers, beta-2 (β 2) antagonists and alpha-2 (α 2) agonists, which are used to treat high ...

  4. Beta1-adrenergic agonist - Wikipedia

    en.wikipedia.org/wiki/Beta1-adrenergic_agonist

    β 1-Adrenergic receptor agonists, also known as beta-1 agonists, are a class of drugs that bind selectively to the β 1-adrenergic receptor. As a result, they act more selectively upon the heart . β-Adrenoceptors typically bind to norepinephrine release by sympathetic adrenergic nerves and to circulating epinephrine .

  5. Beta-adrenergic agonist - Wikipedia

    en.wikipedia.org/wiki/Beta-adrenergic_agonist

    In general, pure beta-adrenergic agonists have the opposite function of beta blockers: beta-adrenoreceptor agonist ligands mimic the actions of both epinephrine- and norepinephrine- signaling, in the heart and lungs, and in smooth muscle tissue; epinephrine expresses the higher affinity.

  6. Adrenergic receptor autoantibodies - Wikipedia

    en.wikipedia.org/wiki/Adrenergic_receptor_auto...

    Refractory Hypertension associated with autoantibodies to beta1-adrenergic receptors has been documented in diabetic patients. [8] While the exact pathophysiology of Chagas disease is not completely understood, some models have shown that an overstimulation of the immune system causes production of adrenergic autoantibodies. Current research is ...

  7. Adrenergic blocking agent - Wikipedia

    en.wikipedia.org/wiki/Adrenergic_blocking_agent

    Beta1 blocker will stop the action of beta-1 receptor via occupying the beta-1 receptor without any activation. [5] The beta-1 receptor is a G-protein-coupled receptor with Gs alpha subunit as its main communication method. [5] By signaling Gs, adenylyl cyclase is recruited to activate a cAMP pathway, which potentiates the receptor. [5]

  8. Adrenergic agonist - Wikipedia

    en.wikipedia.org/wiki/Adrenergic_agonist

    An adrenergic agonist is a drug that stimulates a response from the adrenergic receptors. The five main categories of adrenergic receptors are: α 1, α 2, β 1, β 2, and β 3, although there are more subtypes, and agonists vary in specificity between these receptors, and may be classified respectively. However, there are also other mechanisms ...

  9. Christopher G. Tate - Wikipedia

    en.wikipedia.org/wiki/Christopher_G._Tate

    Tate became an independent group leader in 2010 and since then his group has used structural biology to discover how the beta1-adrenoceptor [8] and the adenosine A2A receptor [9] are activated. In collaboration with the group of Reinhard Grisshammer (NIH, Bethesda), the structure of the thermostabilised neurotensin receptor was determined [ 10 ...