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[3] [5] In reaction to the loss of cartilage, the bones thicken at the joint surface, resulting in subchondral sclerosis. Also, bony outgrowths, called osteophytes (also known as “bone spurs”), are formed at the joint margins. [6] The main symptom is pain, particularly with gripping and pinching.
Diagnosis of this rare disease is often misdiagnosed or delayed, leading to results such as amputation and death. In a rare case, an 80 year old woman displayed symptoms resembling temporal arteritis. However, pathological findings confirmed that it was Mönckeberg's arteriosclerosis instead.
Osteosclerosis is a disorder characterized by abnormal hardening of bone and an elevation in bone density. It may predominantly affect the medullary portion and/or cortex of bone.
Subacute combined degeneration of spinal cord, also known as myelosis funiculus, or funicular myelosis, [1] also Lichtheim's disease, [2] [3] and Putnam-Dana syndrome, [4] refers to degeneration of the posterior and lateral columns of the spinal cord as a result of vitamin B 12 deficiency (most common).
Eburnation is a degenerative process of bone commonly found in patients with osteoarthritis or non-union of fractures.Friction in the joint causes the reactive conversion of the sub-chondral bone to an ivory-like surface at the site of the cartilage erosion. [1]
In current practice patients usually present with hip pain on the side with Chandler's disease. Since this is such a rare diagnosis some more conservative pain control methods are seldom used first before in-depth scans are used that lead to the diagnosis. Based on the staging of the dying bone typically dictates the course of treatment.
Osteochondritis dissecans (OCD or OD) is a joint disorder primarily of the subchondral bone in which cracks form in the articular cartilage and the underlying subchondral bone. [1] OCD usually causes pain during and after sports. In later stages of the disorder there will be swelling of the affected joint that catches and locks during movement.
Patients with limited systemic sclerosis have a better prognosis than those with the diffuse form. Death is most often caused by lung, heart, and kidney involvement. The risk of cancer is increased slightly. [1] Survival rates have greatly increased with effective treatment for kidney failure.
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