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The management of HIV/AIDS normally includes the use of multiple antiretroviral drugs as a strategy to control HIV infection. [1] There are several classes of antiretroviral agents that act on different stages of the HIV life-cycle.
The V-model falls into three broad categories, the German V-Modell, a general testing model, and the US government standard. [2] The V-model summarizes the main steps to be taken in conjunction with the corresponding deliverables within computerized system validation framework, or project life cycle development. It describes the activities to ...
Structural domains of the HIV-1 integrase. The integration of HIV DNA into the host DNA is a critical step in the HIV life cycle. Understanding the integration process will provide a framework for gaining insight into multiple potential sites of therapeutic intervention for HIV infection and AIDS.
IEC 62304 – medical device software – software life cycle processes [1] is an international standard published by the International Electrotechnical Commission (IEC). The standard specifies life cycle requirements for the development of medical software and software within medical devices.
the anticipation of process and effect evaluation. Intervention mapping is characterized by three perspectives: an ecological approach, participation of all stakeholders, and the use of theories and evidence. Although intervention mapping is presented as a series of steps, the authors see the planning process as iterative rather than linear. [1]
[citation needed] The continuance of this model is reliant on the prominence of caretakers. In this way, training the next generation of caretakers must include rotation through HIV units and experience with the many stages of HIV care in order to ensure this model of care remains within hospital settings. [10]
WHO Disease Staging System for HIV Infection and Disease was first produced in 1990 by the World Health Organization [1] and updated in 2007. [2] It is an approach for use in resource limited settings and is widely used in Africa and Asia and has been a useful research tool in studies of progression to symptomatic HIV disease .
Recent studies employed an ex vivo human lymphoid aggregate culture (HLAC) system formed with fresh human tonsil or spleen tissue [8] to model molecular and cellular events in human tissues during in vivo HIV infection. These studies found that >95% of CD4 T cells die because of abortive HIV infection. [9]