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Female dogs bleed during estrus, which usually lasts from 7–13 days, depending on the size and maturity of the dog. Ovulation occurs 24–48 hours after the luteinizing hormone peak, which occurs around the fourth day of estrus; therefore, this is the best time to begin breeding.
During gastrulation cells migrate to the interior of the blastula, subsequently forming two (in diploblastic animals) or three (triploblastic) germ layers. The embryo during this process is called a gastrula. The germ layers are referred to as the ectoderm, mesoderm and endoderm.
Oogenesis (/ ˌ oʊ. ə ˈ dʒ ɛ n ɪ s ɪ s /) or ovogenesis is the differentiation of the ovum (egg cell) into a cell competent to further develop when fertilized. [1] It is developed from the primary oocyte by maturation. Oogenesis is initiated before birth during embryonic development.
In vertebrates, ova are produced by female gonads (sex glands) called ovaries. A number of ova are present at birth in mammals and mature via oogenesis. Studies performed on humans, dogs, and cats in the 1870s suggested that the production of oocytes (immature egg cells) stops at or shortly after birth
Only during estrus will copulation result in pregnancy. During proestrus and estrus, females may have a clear, blood tinged, or bloody discharge. Dogs during these stages are often informally referred to as being in heat. The length of these cycles varies greatly among breeds and even between individuals of the same breed.
A polar body is a small haploid cell that is formed at the same time as an egg cell during oogenesis, but generally does not have the ability to be fertilized. It is named from its polar position in the egg. When certain diploid cells in animals undergo cytokinesis after meiosis to produce egg cells, they sometimes divide unevenly.
During the primary oocyte stage of oogenesis, the nucleus is called a germinal vesicle. [ 2 ] The only normal human type of secondary oocyte has the 23rd (sex) chromosome as 23,X (female-determining), whereas sperm can have 23,X (female-determining) or 23,Y (male-determining).
The zona pellucida is a translucent matrix of cross-linked glycoprotein filaments that surrounds the mammalian oocyte and is 6.5–20 μm thick depending on the species. Its formation, which depends on a conserved zona pellucida-like (ZP) module that mediates the polymerization of egg coat components, [2] is critical to successful fertilization. [3]