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Female dogs bleed during estrus, which usually lasts from 7–13 days, depending on the size and maturity of the dog. Ovulation occurs 24–48 hours after the luteinizing hormone peak, which occurs around the fourth day of estrus; therefore, this is the best time to begin breeding.
Only during estrus will copulation result in pregnancy. During proestrus and estrus, females may have a clear, blood tinged, or bloody discharge. Dogs during these stages are often informally referred to as being in heat. The length of these cycles varies greatly among breeds and even between individuals of the same breed.
Oogenesis (/ ˌ oʊ. ə ˈ dʒ ɛ n ɪ s ɪ s /) or ovogenesis is the differentiation of the ovum (egg cell) into a cell competent to further develop when fertilized. [1] It is developed from the primary oocyte by maturation. Oogenesis is initiated before birth during embryonic development.
During gastrulation cells migrate to the interior of the blastula, subsequently forming two (in diploblastic animals) or three (triploblastic) germ layers. The embryo during this process is called a gastrula. The germ layers are referred to as the ectoderm, mesoderm and endoderm.
The zona pellucida is a translucent matrix of cross-linked glycoprotein filaments that surrounds the mammalian oocyte and is 6.5–20 μm thick depending on the species. Its formation, which depends on a conserved zona pellucida-like (ZP) module that mediates the polymerization of egg coat components, [2] is critical to successful fertilization. [3]
During the primary oocyte stage of oogenesis, the nucleus is called a germinal vesicle. [2] The only normal human type of secondary oocyte has the 23rd (sex) chromosome as 23,X (female-determining), whereas sperm can have 23,X (female-determining) or 23,Y (male-determining).
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Also called the domestic dog, it was selectively bred from an extinct population of wolves during the Late Pleistocene by hunter-gatherers. The dog was the first species to be domesticated by humans , over 14,000 years ago and before the development of agriculture .