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The end-bulbs of Krause were thought to be thermoreceptors, sensing cold temperatures, but in early research their function remained unknown. [3] Recently optogenetic studies revealed their role in sexual stimulation and mating behavior in mice:
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Krause discovered and described mechanoreceptors that were to become known as "Krause's corpuscles", sometimes referred to as "Krause's end-bulbs". [citation needed] His name is also associated with: "Krause's membranes": defined as isotropic bands in striated muscle fiber that consist of disks of sarcoplasm and connect the individual fibrils ...
The end-bulb of Krause or bulboid corpuscle detects temperatures above body temperature. Ruffini's end organ detects temperatures below body temperature. TRPV1 is a heat-activated channel that acts as a small heat detecting thermometer in the membrane which begins the polarization of the neural fiber when exposed to changes in temperature.
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[3] 20 to 40 glands of Krause are found in the upper fornix, and 6-8 glands appear in the lower fornix. [4] There are usually 2 to 5 Ciaccio's glands, and are found along the superior tarsal border of the upper eyelid. [1] Popov’s glands are located within the substance of the caruncle. [1]