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Vibrio cholerae is a species ... Some strains of V. cholerae are pathogenic to humans and cause a ... and recombination of different V. cholerae genes can lead to ...
Cholera toxin (also known as choleragen and sometimes abbreviated to CTX, Ctx or CT) is an AB5 multimeric protein complex secreted by the bacterium Vibrio cholerae. [1] [2] CTX is responsible for the massive, watery diarrhea characteristic of cholera infection. [3] It is a member of the heat-labile enterotoxin family.
As V. cholerae multiplies, genes of the virulence factors are expressed as amount of CAI-1 accumulates including the ones that encode for the cholera toxin. This toxin has the ability to disrupt electrolyte balance in intestinal epithelial cells which can lead to issues including severe diarrhea, which is known to be a common symptom of this ...
Cholera (/ ˈ k ɒ l ər ə /) is an infection of the small intestine by some strains of the bacterium Vibrio cholerae. [4] [3] Symptoms may range from none, to mild, to severe. [3]The classic symptom is large amounts of watery diarrhea lasting a few days. [2]
V. cholerae is generally transmitted by contaminated water. [3] Pathogenic Vibrio species can cause foodborne illness (infection), usually associated with eating undercooked seafood. [18] When ingested Vibrio bacteria can primarily result in watery diarrhea along with other secondary symptoms. [19]
CTXφ is generally present and integrated into the genome of the V. cholerae bacterium, and more rarely in a virion from outside the bacterium. While integrated into the bacterial genome, CTX prophages are found on each of the two chromosomes (in the O1 serogroup of V. cholerae) or arranged in tandem on the larger chromosome (in the El Tor biotype of V. cholerae). [2]
The PRCC1 gene has two distinct regions: a proline-rich region on the N-terminus, and the DUF84 region on the C-terminus. The DUF84 region is found in the genome of a bacterium called Vibrio cholerae. [2] The region consists of approximately 183 amino acid residues. V. cholerae causes cholera and stomach flu in humans. The DUF84 region alone is ...
In Vibrio cholerae T6SS studies, it has been observed that serotype O37 has high vas gene expression. Serotypes O139 and O1 on the other hand exhibit the opposite, with markedly low vas gene expression. It has been suggested that the differences in expression are attributable to differences in quorum-sensing levels.