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  2. Methylene blue - Wikipedia

    en.wikipedia.org/wiki/Methylene_blue

    Methylthioninium chloride, commonly called methylene blue, is a salt used as a dye and as a medication. As a medication, it is mainly used to treat methemoglobinemia.It has previously been used for treating cyanide poisoning and urinary tract infections, but this use is no longer recommended.

  3. Intrathecal administration - Wikipedia

    en.wikipedia.org/wiki/Intrathecal_administration

    This route is also used to introduce drugs that fight certain infections, particularly post-neurosurgical. Typically, the drug is given this way to avoid being stopped by the blood–brain barrier, as it may not be able to pass into the brain when given orally. Drugs given by the intrathecal route often have to be compounded specially by a ...

  4. Antimicrobial photodynamic therapy - Wikipedia

    en.wikipedia.org/wiki/Antimicrobial_Photodynamic...

    The most widely employed photosensitizer in clinical practice is the phenothiazine derivative, methylene blue, which carries a +1 charge. [27] Methylene blue is also favored due to its long record of safe use in patients, both in surgical staining and the systemic treatment of methemoglobinemia. [28]

  5. MDMA - Wikipedia

    en.wikipedia.org/wiki/MDMA

    Administration of MDMA to mice causes DNA damage in their brain, [83] especially when the mice are sleep deprived. [84] Even at the very low doses that are comparable to those self-administered by humans, MDMA causes oxidative stress and both single and double-strand breaks in the DNA of the hippocampus region of the mouse brain. [85]

  6. New methylene blue - Wikipedia

    en.wikipedia.org/wiki/New_methylene_blue

    New methylene blue (also NMB) [clarify] is an organic compound of the thiazine class of heterocycles. It is used as a stain and as an antimicrobial agent. It is classified as an azine dye, and the chromophore is a cation, the anion is often unspecified.

  7. Intranasal drug delivery - Wikipedia

    en.wikipedia.org/wiki/Intranasal_drug_delivery

    Treating brain diseases has been a challenge due to the blood brain barrier. Previous studies evaluated the efficacy of delivery therapeutics through intranasal route for brain diseases and mental health conditions. Intranasal administration is a potential route associated with high drug transfer from nose to brain and drug bioavailability. [1]

  8. Blood–brain barrier - Wikipedia

    en.wikipedia.org/wiki/Blood–brain_barrier

    Infections of the brain that do occur are often difficult to treat. Antibodies are too large to cross the blood–brain barrier, and only certain antibiotics are able to pass. [16] In some cases, a drug has to be administered directly into the cerebrospinal fluid where it can enter the brain by crossing the blood-cerebrospinal fluid barrier ...

  9. Cyanosis - Wikipedia

    en.wikipedia.org/wiki/Cyanosis

    In patients with significant respiratory distress, supplemental oxygen (in the form of nasal canula or continuous positive airway pressure depending on severity) should be given immediately. [10] [11] If the methemoglobin levels are positive for methemoglobinemia, first-line treatment is to administer methylene blue. [1]

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