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Fournier's gangrene, a rare but serious infection of the groin, occurs more commonly in people taking empagliflozin and other SGLT-2 inhibitors. [2] [15] Symptoms include feverishness, a general sense of malaise, and pain or swelling around the genitals or in the skin behind them. The infection progresses quickly and urgent medical attention is ...
Fournier gangrene is usually diagnosed clinically, but laboratory tests and imaging studies are used to confirm diagnosis, determine severity, and predict outcomes. [2] X-rays and ultrasounds may show the presence of gas below the surface of the skin. [2] A CT scan can be useful in determining the site of origin and extent of spread. [2]
Empagliflozin, approved in the United States in August 2014, under the brand name Jardiance by Boehringer Ingelheim. [30] Of the gliflozins, empagliflozin and tofogliflozin have the highest specificity for SGLT2 inhibition. [1] This oral medicine for type 2 diabetes has been shown to reduce the risk of cardiovascular death. [31]
Later, "hospital gangrene" became more commonly used. In 1871, Confederate States Army surgeon Joseph Jones reported 2,642 cases of hospital gangrene with a mortality rate of 46%. In 1883, Dr Jean-Alfred Fournier described necrotizing infections of the perineum and scrotum, now named after him as Fournier gangrene. The term "necrotizing ...
Bexagliflozin may also cause serious side effects such as an increased incidence for surgery to remove parts of the legs or feet, decreases in blood pressure due to excessive loss of water and sodium from the body, serious infections in the genital region (Fournier’s gangrene), very low blood sugar levels when used in combination with insulin ...
Gangrene is a type of tissue death caused by a lack of blood supply. [4] The feet and hands are most commonly affected. [1] If the gangrene is caused by an infectious agent, it may present with a fever or sepsis. [1] Symptoms may include: [1] a change in skin color to red or black; numbness; swelling; pain; skin breakdown; coolness
Serious but rare side effects include Fournier gangrene. [16] It was developed by Bristol-Myers Squibb in partnership with AstraZeneca. It is on the World Health Organization's List of Essential Medicines. [17] In 2022, it was the 115th most commonly prescribed medication in the United States, with more than 5 million prescriptions.
Fournier's gangrene: gangrene caused by infection of the scrotum and usually associated with diabetes. Although the condition is named after Fournier after he published a series of five cases, [2] it was first described by a physician named Baurienne in 1764. [3] Fournier's sign: scars on the mouth following the healing of lesions in congenital ...