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Spironolactone has been found to increase LDL ("bad") cholesterol and decrease HDL ("good") cholesterol levels at the relatively high doses used in women with polycystic ovary syndrome (PCOS). [ 149 ] [ 150 ] As such, it may have unfavorable effects on the blood lipid profile in this context.
Polycystic ovary syndrome, or polycystic ovarian syndrome (PCOS), is the most common endocrine disorder in women of reproductive age. [14] The syndrome is named after cysts which form on the ovaries of some women with this condition, though this is not a universal symptom and not the underlying cause of the disorder.
The AR antagonism of spironolactone mostly underlies its antiandrogenic activity and is the major mechanism responsible for its therapeutic benefits in the treatment of androgen-dependent conditions like acne, hirsutism, and pattern hair loss and its usefulness in hormone therapy for transgender women.
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According to the U.S. Office on Women's Health, PCOS is a health problem caused by an imbalance of reproductive hormones, which affects how the ovaries (organs that make eggs and hormones that ...
Hyperandrogenism is a medical condition characterized by high levels of androgens.It is more common in women than men. [4] Symptoms of hyperandrogenism may include acne, seborrhea, hair loss on the scalp, increased body or facial hair, and infrequent or absent menstruation.
Some women have more follicles than usual (polycystic ovary syndrome), which inhibits the follicles to grow normally and this will cause cycle irregularities. Various types of ovarian diseases exist. Some of the ovarian diseases or disorders include: endometriosis , ovarian cysts , ovarian epithelial cancer , ovarian germ cell tumors , ovarian ...
Research shows that women with PCOS who achieve a healthy weight via lifestyle changes have a better quality of life and fewer medical complications associated with PCOS. More Movement