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Multiple myeloma (MM), also known as plasma cell myeloma and simply myeloma, is a cancer of plasma cells, a type of white blood cell that normally produces antibodies. [6] Often, no symptoms are noticed initially. [10] As it progresses, bone pain, anemia, renal insufficiency, and infections may occur. [10]
The American Heritage Dictionary of the English Language (abbreviated AHD) uses a phonetic notation based on the Latin alphabet to transcribe the pronunciation of spoken English. It and similar respelling systems, such as those used by the Merriam-Webster and Random House dictionaries, are familiar to US schoolchildren.
Diagram showing the development of different blood cells from haematopoietic stem cell to mature cells Comprehensive diagram that shows the development of different blood cells from haematopoietic stem cell to mature cells in both myeloid and lymphoid lineages.
The following table shows the 24 consonant phonemes found in most dialects of English, plus /x/, whose distribution is more limited. Fortis consonants are always voiceless, aspirated in syllable onset (except in clusters beginning with /s/ or /ʃ/), and sometimes also glottalized to an extent in syllable coda (most likely to occur with /t/, see T-glottalization), while lenis consonants are ...
For example, you may pronounce cot and caught, do and dew, or marry and merry the same. This often happens because of dialect variation (see our articles English phonology and International Phonetic Alphabet chart for English dialects). If this is the case, you will pronounce those symbols the same for other words as well. [1]
POEMS syndrome (also termed osteosclerotic myeloma, Crow–Fukase syndrome, Takatsuki disease, or PEP syndrome) is a rare paraneoplastic syndrome caused by a clone of aberrant plasma cells. The name POEMS is an acronym for some of the disease's major signs and symptoms ( p olyneuropathy , o rganomegaly , e ndocrinopathy , m yeloma protein , and ...
Plasmacytoma is a plasma cell dyscrasia in which a plasma cell tumour grows within soft tissue or within the axial skeleton.. The International Myeloma Working Group lists three types: solitary plasmacytoma of bone (SPB); extramedullary plasmacytoma (EP), and multiple plasmacytomas that are either primary or recurrent. [1]
MPNs arise when precursor cells (blast cells) of the myeloid lineages in the bone marrow develop somatic mutations which cause them to grow abnormally. There is a similar category of disease for the lymphoid lineage, the lymphoproliferative disorders acute lymphoblastic leukemia, lymphomas, chronic lymphocytic leukemia and multiple myeloma. [4]