Ad
related to: brca2 gene location map
Search results
Results from the WOW.Com Content Network
675 12190 Ensembl ENSG00000139618 ENSMUSG00000041147 UniProt P51587 P97929 RefSeq (mRNA) NM_000059 NM_001081001 NM_009765 RefSeq (protein) NP_000050 NP_001074470 NP_033895 Location (UCSC) Chr 13: 32.32 – 32.4 Mb Chr 5: 150.45 – 150.49 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse BRCA2 and BRCA2 are human genes and their protein products, respectively. The official symbol ...
Inheriting one BRCA1 mutation and one BRCA2 mutation has been reported occasionally; the child's risk for any given type of cancer is the higher risk of the two genes (e.g., the ovarian cancer risk from BRCA1 and the pancreatic cancer risk from BRCA2). Inheriting two BRCA2 mutations produces Fanconi anemia. [9]: 82–85
The PALB2 protein acts as a hub, [12] bringing together BRCA1, BRCA2 and RAD51 at the site of a DNA double-strand break, and also binds to RAD51C, a member of the RAD51 paralog complex RAD51B-RAD51C-RAD51D-XRCC2 (BCDX2). The BCDX2 complex is responsible for RAD51 recruitment or stabilization at damage sites. [13]
BRCC36, the protein product of the BRCC3 gene, is a deubiquitinating enzyme and a core component of the deubiquitin complex BRCA1-A. [8] BRCA1, as distinct from BRCA1-A, is employed in the repair of chromosomal damage with an important role in the error-free homologous recombinational (HR) repair of DNA double-strand breaks.
Mutations in genes responsible for HR are prevalent among human cancers. The BRCA1 and BRCA2 genes are centrally involved in HR, DNAdamage repair, end resection, and checkpoint signaling. Mutational signatures of HRD have been identified in over 20% of breast cancers, as well as pancreatic, ovarian, and gastric cancers.
66165 Ensembl ENSG00000107949 ENSMUSG00000030983 UniProt Q9P287 Q9CWI3 RefSeq (mRNA) NM_078469 NM_016567 NM_078468 NM_025392 RefSeq (protein) NP_057651 NP_510868 NP_510869 NP_079668 Location (UCSC) Chr 10: 125.82 – 125.85 Mb Chr 7: 133.31 – 133.32 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse BRCA2 and CDKN1A-interacting protein is a protein that is encoded by the BCCIP gene in ...
BRCA2 (gene) From Wikipedia, the free encyclopedia. ... This is a redirect from a Human Genome Organisation (HUGO) symbol for a gene to an article about the gene.
The major genetic risk factor for ovarian cancer is a mutation in BRCA1 or BRCA2 genes, or in DNA mismatch repair genes, which is present in 10% of ovarian cancer cases. Only one allele needs to be mutated to place a person at high risk. The gene can be inherited through either the maternal or paternal line, but has variable penetrance.
Ad
related to: brca2 gene location map