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Luspatercept is indicated for the treatment of adults with transfusion-dependent anemia due to very low, low and intermediate-risk myelodysplastic syndromes (MDS) with ring sideroblasts, who had an unsatisfactory response to or are ineligible for erythropoietin-based therapy.
Acceleron Pharma, Inc. is an American clinical stage biopharmaceutical company based in Cambridge, Massachusetts with a broad focus on developing medicines that regulate the transforming growth factor beta (TGF-β) superfamily of proteins, which play fundamental roles in the growth and repair of cells and tissues such as red blood cells, muscle, bone, and blood vessels.
Luspatercept (ACE-536) is a recombinant fusion protein that is used as a treatment in adults with transfusion dependent beta thalassemia. It consists of a modified extra-cellular domain of human activin receptor type IIB bound to the Fc portion of the human IgG1 antibody. [ 8 ]
The Atlantic City Expressway, officially numbered, but unsigned, as Route 446 and abbreviated A.C. Expressway, ACE, or ACX, and known locally as the Expressway, is a 44.1-mile (70.97 km) controlled-access toll road in the U.S. state of New Jersey, managed and operated by the South Jersey Transportation Authority.
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Ace Books began its second G-series in 1964, and it ran until 1968, with serial numbers from 501 to 766. There had previously been nine titles with a G prefix published as part of the D/G/S-series. These nine are: G-352 NA Francis Leary Fire And Morning (1959) G-371 NA Theodor Plievier Berlin (1959) G-376 NA J. Harvey Howells The Big Company ...
D-536 NA Peggy Gaddis The Nurse and the Pirate (1961) D-537 SF H. G. Wells The Island of Dr. Moreau (1961) D-538 SF Isaac Asimov The 1,000 Year Plan (1961) D-539 NA Mary Mann Fletcher Psychiatric Nurse (1962) D-540 NA Arlene Hale School Nurse (1962) D-541 SF Alan E. Nourse Scavengers in Space (1962) D-542 SF Andre Norton The Last Planet (1962)
The volcanic winter of 536 was the most severe and protracted episode of climatic cooling in the Northern Hemisphere in the last 2,000 years. [1] The volcanic winter was caused by at least three simultaneous eruptions of uncertain origin, with several possible locations proposed in various continents.