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Dicloxacillin is a narrow-spectrum β-lactam antibiotic of the penicillin class. [1] It is used to treat infections caused by susceptible (non-resistant) Gram-positive bacteria . [ 1 ] It is active against beta-lactamase -producing organisms such as Staphylococcus aureus , which would otherwise be resistant to most penicillins .
Dicloxacillin: Dynapen (discontinued) Flucloxacillin: Floxapen (Sold to European generics Actavis Group) Mezlocillin: Mezlin (discontinued) Methicillin: Staphcillin (discontinued) Nafcillin: Unipen (discontinued) Oxacillin: Prostaphlin (discontinued) Penicillin G: Pentids (discontinued) Penicillin V: Veetids (Pen-Vee-K) (discontinued) Piperacillin
The usual dose by mouth is one capsule of 250 mg 4 times a day in adults and half the adult dose as a syrup for children under the age of 10 years but over 2. [4] For children below the age of 2 years, the oral dose is a quarter of the adult oral dose. [3] Ampicillin/flucloxacillin is taken orally about half an hour before food. [5]
Cloxacillin is an antibiotic useful for the treatment of several bacterial infections. [1] This includes impetigo , cellulitis , pneumonia , septic arthritis , and otitis externa . [ 1 ] It is not effective for methicillin-resistant Staphylococcus aureus (MRSA). [ 2 ]
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The extended-spectrum penicillins are a group of antibiotics that have the widest antibacterial spectrum of all penicillins. [1] Some sources identify them with antipseudomonal penicillins, [2] others consider these types to be distinct. [3]
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Flucloxacillin and dicloxacillin showed particular stability against the beta-lactamase enzyme of Staph. aureus and could withstand acid. [ 29 ] [ 30 ] Beecham further developed cloxacillin and popularised flucloxacillin in the UK, while Bristol Laboratories concentrated on marketing oxacillin and dicloxacillin in the United States, leading to ...
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