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Statistical significance. In statistical hypothesis testing, [1][2] a result has statistical significance when a result at least as "extreme" would be very infrequent if the null hypothesis were true. [3] More precisely, a study's defined significance level, denoted by , is the probability of the study rejecting the null hypothesis, given that ...
t. -test. Student's t-test is a statistical test used to test whether the difference between the response of two groups is statistically significant or not. It is any statistical hypothesis test in which the test statistic follows a Student's t -distribution under the null hypothesis. It is most commonly applied when the test statistic would ...
Most frequently, t statistics are used in Student's t-tests, a form of statistical hypothesis testing, and in the computation of certain confidence intervals. The key property of the t statistic is that it is a pivotal quantity – while defined in terms of the sample mean, its sampling distribution does not depend on the population parameters, and thus it can be used regardless of what these ...
For example, the test statistic might follow a Student's t distribution with known degrees of freedom, or a normal distribution with known mean and variance. Select a significance level (α), the maximum acceptable false positive rate. Common values are 5% and 1%. Compute from the observations the observed value t obs of the test statistic T.
In broad usage, the "practical clinical significance" answers the question, how effective is the intervention or treatment, or how much change does the treatment cause. In terms of testing clinical treatments, practical significance optimally yields quantified information about the importance of a finding, using metrics such as effect size, number needed to treat (NNT), and preventive fraction ...
p. -value. In null-hypothesis significance testing, the p-value[note 1] is the probability of obtaining test results at least as extreme as the result actually observed, under the assumption that the null hypothesis is correct. [2][3] A very small p -value means that such an extreme observed outcome would be very unlikely under the null hypothesis.
Sample size determination or estimation is the act of choosing the number of observations or replicates to include in a statistical sample. The sample size is an important feature of any empirical study in which the goal is to make inferences about a population from a sample. In practice, the sample size used in a study is usually determined ...
In statistics, an effect size is a value measuring the strength of the relationship between two variables in a population, or a sample-based estimate of that quantity. It can refer to the value of a statistic calculated from a sample of data, the value of a parameter for a hypothetical population, or to the equation that operationalizes how statistics or parameters lead to the effect size ...