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Structure of the RNA genome of HIV-1. HIV has several major genes coding for structural proteins that are found in all retroviruses as well as several nonstructural ("accessory") genes unique to HIV. [27] The HIV genome contains nine genes that encode fifteen viral proteins. [28]
HIV (Human Immunodeficiency Virus) is composed of two strands of RNA, 15 types of viral proteins, and a few proteins from the last host cell it infected, all surrounded by a lipid bilayer membrane.
HIV structure and organisation. HIV is classified into the family Retroviridae, subfamily Lentiviridae, and genus Lentivirus [20, 21]. The structure of HIV follows the typical pattern of a complex retrovirus family, comprising a single-stranded, positive-sense ribonucleic acid (RNA) genome of about 9.2 kilobases that encodes structural ...
The X-ray crystal structure of the HIV-1 RT heterodimer reveals the asymmetrical nature of the protein complex and the binding site for the NNRTIs, such as nevirapine.
This chapter describes our current understanding of HIV’s virion architecture and its dynamic transformations: the process of virion assembly as orchestrated by Gag, the architecture of the immature virion, the virus maturation process, and the structure of the mature capsid.
Structure of HIV. Cross-sectional schematic diagram of HIV virion. Each virion expresses 72 glycoprotein projections composed of gp120 (orange) and gp41 (light blue). Gp41 is a transmembrane molecule that crosses the lipid bilayer of the envelope.
This paper and related structural work from Edward Arnold and colleagues published around the same time, as well as structures that soon followed, set the stage for the design of more effective...
This chapter describes our current understanding of HIV's virion architecture and its dynamic transformations: the process of virion assembly as orchestrated by Gag, the architecture of the immature virion, the virus maturation process, and the structure of the mature capsid.
This article summarizes the high-resolution structural information that is currently available for HIV proteins and reviews current structure-function and structure-biological relationships.
The human immunodeficiency virus (HIV) genome encodes a total of three structural proteins, two envelope proteins, three enzymes, and six accessory proteins.