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Macrolides belong to the polyketide class of natural products. Some macrolides have antibiotic or antifungal activity and are used as pharmaceutical drugs. Rapamycin is also a macrolide and was originally developed as an antifungal, but has since been used as an immunosuppressant drug and is being investigated as a potential longevity ...
Carbomycin, also known as magnamycin, is a colorless, optically active crystalline [1] macrolide antibiotic with the molecular formula C 42 H 67 N O 16.It is derived from the bacterium Streptomyces halstedii and active in inhibiting the growth of Gram-positive bacteria and "certain Mycoplasma strains."
The bafilomycins are a family of macrolide antibiotics produced from a variety of Streptomycetes. Their chemical structure is defined by a 16-membered lactone ring scaffold. [2] Bafilomycins exhibit a wide range of biological activity, including anti-tumor, [3] anti-parasitic, [4] [5] immunosuppressant [6] and anti-fungal [7] activity.
Pages in category "Macrolide antibiotics" The following 45 pages are in this category, out of 45 total. This list may not reflect recent changes. A. Aigialomycin D;
Azalides such as azithromycin are a class of macrolide antibiotics that were originally manufactured in response to the poor acid stability exhibited by original macrolides (erythromycin). [1] Following the clinical overuse of macrolides and azalides, ketolides have been developed to combat surfacing macrolide-azalide resistance among ...
It is in the macrolide class and works by slowing down bacterial protein synthesis. [3] Clarithromycin resistance is already a major challenge to healthcare systems and such resistance is spreading, leading to recommendations to test the susceptibility of pathogenic organisms to the antibiotic before commencing clarithromycin therapy. [4]
Azithromycin is a member of macrolides that are a class of antibiotics with a cyclic structure with a lactone ring and sugar moieties. Macrolides can inhibit CYP3A4 by a mechanism called mechanism-based inhibition (MBI), which involves the formation of reactive metabolites that bind covalently and irreversibly to the enzyme, rendering it inactive.
The series of conjugated double bonds typically absorbs strongly in the ultraviolet-visible region of the electromagnetic spectrum, often resulting in the polyene antibiotics having a yellow color. Chemical structure of Amphotericin B. Amphotericin B is an example of a yellow polyene antimycotic agent.
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