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Enclomifene is the (E)-stereoisomer of clomifene, while zuclomifene is the (Z)-stereoisomer. [ 4 ] [ 5 ] Whereas zuclomifene is more estrogenic , enclomifene is more antiestrogenic . [ 3 ] In accordance, unlike enclomifene, zuclomifene is antigonadotropic due to activation of the ER and reduces testosterone levels in men. [ 3 ]
Clomifene has an onset of action of 5 to 10 days following course of treatment and an elimination half-life about 4 - 7days. [2] [4] In one study, after a single 50 mg dose of clomifene, the half-life of clomifene was 128 hours (5.3 days), of 4-hydroxyclomifene was 13 hours, and of 4-hydroxy-N-desmethylclomifene was 15 hours. [2]
Hypogonadism means diminished functional activity of the gonads —the testicles or the ovaries —that may result in diminished production of sex hormones. Low androgen (e.g., testosterone) levels are referred to as hypoandrogenism and low estrogen (e.g., estradiol) as hypoestrogenism. These are responsible for the observed signs and symptoms ...
Sildenafil (Viagra) and vardenafil (Levitra) are short-acting. These “one-night” ED medications are both available as generics, making them good medications to try first. Tadalafil (Cialis) is ...
Condom-associated erection problem (CAEP) is erectile dysfunction experienced due to condoms. [1] CAEP can occur in young and healthy men who otherwise have no erectile dysfunctions, although men who experience CAEP have greater odds of having mild-to-moderate erectile dysfunction. CAEP has the effect of discouraging condom use by both males ...
Erectile dysfunction (ED), also referred to as impotence, is a form of sexual dysfunction in males characterized by the persistent or recurring inability to achieve or maintain a penile erection with sufficient rigidity and duration for satisfactory sexual activity. It is the most common sexual problem in males and can cause psychological ...
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