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Brimonidine is an α 2 agonist medication used to treat open-angle glaucoma, ocular hypertension, and rosacea. [4] [5] In rosacea it improves the redness. [5] It is used as eye drops or applied to the skin. [4] [5] It is also available in the fixed-dose combination medication brimonidine/timolol along with timolol maleate. [6]
An expiration date or expiry date is a previously determined date after which something should no longer be used, either by operation of law or by exceeding the anticipated shelf life for perishable goods. Expiration dates are applied to some food products and other products like infant car seats where the age of the product may affect its safe ...
The period-after-opening symbol or PAO symbol is a graphic symbol that identifies the useful lifetime of a cosmetic product after its package has been opened for the first time. It depicts an open cosmetics pot and is used together with a written number of months or years.
Drug expiration is the date after which a drug might not be suitable for use as manufactured. Consumers can determine the shelf life for a drug by checking its pharmaceutical packaging for an expiration date. Drugs which are past their shelf life can decompose [1] and either be ineffective [2] or even harmful. [2]
The expiration date of pharmaceuticals specifies the date the manufacturer guarantees the full potency and safety of a drug. Most medications continue to be effective and safe for a time after the expiration date. A rare exception is a case of renal tubular acidosis purportedly caused by expired tetracycline. [9]
Contraindications of brimonidine/timolol include the following: reactive airway disease including bronchial asthma, a history of bronchial asthma, severe chronic obstructive pulmonary disease, sinus bradycardia, secondary or third degree atrioventricular block, overt cardiac failure, cardiogenic shock, age less than 2 years, and hypersensitivity to any component of brimonidine/timolol.
Big Bear Stores was founded in November 1933 by Wayne E. Brown. The first Big Bear Store opened on February 15, 1934, on West Lane Avenue in Columbus, Ohio, in what was once a dance hall, a roller skating rink and finally a tan bark ring for horse shows. This opening marked the beginning of self-service supermarketing in the Midwest.
Seaway Food Town, Inc. was a company that operated the Food Town chain of supermarkets and The Pharm chain of discount drug stores in Northwest Ohio and Southeast Michigan. Based in Maumee, Ohio , it was founded in 1948 as a buying and advertising cooperative, incorporated as Seaway Food Town in 1957, and became a publicly traded company in the ...