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List of side effects of estradiol which may occur as a result of its use or have been associated with estrogen and/or progestogen therapy includes: [1] [2]. Gynecological: changes in vaginal bleeding, dysmenorrhea, increase in size of uterine leiomyomata, vaginitis including vaginal candidiasis, changes in cervical secretion and cervical ectropion, ovarian cancer, endometrial hyperplasia ...
It contains ethinylestradiol, an estrogen, and etonogestrel, a progestin. [2] It is used by insertion into the vagina. [1] Pregnancy occurs in about 0.3% of women with perfect use and 9% of women with typical use. [3] Common side effects include irregular vaginal bleeding, nausea, sore breasts, vaginitis, mood changes, and headache. [4]
As unopposed estrogen therapy (using estrogen alone without progesterone) increases the risk of endometrial hyperplasia and endometrial cancer in women with intact uteruses, estradiol is usually combined with a progestogen like progesterone or medroxyprogesterone acetate to prevent the effects of estradiol on the endometrium.
Side effects of estrogens include breast tenderness, breast enlargement, headache, nausea, and edema among others. [1] Other side effects of estrogens include an increased risk of blood clots, cardiovascular disease, and, when combined with most progestogens, breast cancer. [1]
Ethinylestradiol (EE) is an estrogen medication which is used widely in birth control pills in combination with progestins. [7] [8] In the past, EE was widely used for various indications such as the treatment of menopausal symptoms, gynecological disorders, and certain hormone-sensitive cancers.
Examples of such side effects include breast tenderness and enlargement, nausea, vomiting, bloating, edema, headache, migraine, and melasma. [ 54 ] [ 55 ] High-dose estrogen therapy with estradiol cypionate injections may also cause an increased risk of thromboembolism , changes in blood lipid profile , increased insulin resistance , and ...
Side effects of estradiol valerate include breast tenderness, breast enlargement, nausea, headache, and fluid retention. [15] [13] [14] Estradiol valerate is an estrogen and hence is an agonist of the estrogen receptor, the biological target of estrogens like estradiol. [5] [4] [16] It is an estrogen ester and a prodrug of estradiol in the body.
Side effects of estradiol enantate include breast tenderness, breast enlargement, nausea, headache, and fluid retention. [16] Estradiol enantate is an estrogen and hence is an agonist of the estrogen receptor, the biological target of estrogens like estradiol. [6] [5] It is an estrogen ester and a long-lasting prodrug of estradiol in the body.