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Progressive retinal atrophy (PRA) is a group of genetic diseases seen in certain breeds of dogs and, more rarely, cats. Similar to retinitis pigmentosa in humans, [ 1 ] it is characterized by the bilateral degeneration of the retina , causing progressive vision loss culminating in blindness.
Progressive bifocal chorioretinal atrophy, also known for its abbreviations PBCRA or CRAPB, [1] is a rare, slowly progressive, autosomal dominant syndrome characterized by relatively large-sized atrophic hole-shaped lesions in the macular and nasal retina, myopia, low visual acuity, and nystagmus.
Sudden acquired retinal degeneration syndrome (SARDS) is a disease in dogs causing sudden blindness. It can occur in any breed, but female dogs may be predisposed. [ 1 ] Approximately 4000 cases are seen in the United States annually.
The most common sign of CEA is the presence of an area of undeveloped choroid (appearing as a pale spot) lateral to the optic disc. The choroid is a collection of blood vessels supplying the retina. CEA can also cause retinal or scleral coloboma, coloboma of the optic disc, retinal detachment, or intraocular hemorrhage.
The angiography test will usually show one or more fluorescent spots with fluid leakage. In 10%-15% of the cases these will appear in a classic smokestack shape. [citation needed] Differential diagnosis should be immediately performed to rule out retinal detachment, which is a medical emergency. A clinical record should be taken to keep a ...
A genetic test is available for progressive retinal atrophy (type crd3), a congenital disorder that gradually results in blindness beginning at about five years of age. As blindness from this cause did not become apparent until well into the breeding years, it was difficult to breed out this trait before the advent of the test.
Cone dystrophy; Fundus of a 45 year-old patient with cone rod dystrophy segregating with a loss-of-function mutation (E1087X) in ABCA4. Note the presence of various-shaped pigment deposits in the posterior pole with atrophy of the retina, while the retina appears less damaged in periphery (upper part of the photograph).
Retinal degeneration may refer to: Retinopathy, one of several eye diseases or eye disorders in humans ... Progressive retinal atrophy, an eye disease in dogs; See also