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The klotho protein is a novel β-glucuronidase (EC number 3.2.1.31) capable of hydrolyzing steroid β-glucuronides. Genetic variants in KLOTHO have been associated with human aging, [22] and klotho protein has been shown to be a circulating factor detectable in serum that declines with age. [23]
[12] [13] [14] It has since been shown that Klotho can act to protect against Parkinson's and multiple sclerosis. [7] The mechanisms that underpin Klotho's enhancement of cognitive ability are still unknown. [7] Alongside working on mouse models, in 2019, Dubal was the first to show that Klotho may protect people from Alzheimer's disease.
The longest documented human lifespan is 122 years 164 days, the case of Jeanne Calment, who according to records was born in 1875 and died in 1997, whereas the maximum lifespan of a wildtype mouse, commonly used as a model in research on aging, is about three years. [10]
Life expectancy for population in general Life expectancy for male Life expectancy for female Sex gap Population (thous.) at birth bonus 0→15 at 15 bonus 15→65 at 65 bonus 65→80 at 80 at birth at 15 at 65 at 80 at birth at 15 at 65 at 80 at birth at 15 at 65 at 80 Australia/New Zealand: 83.62: 0.38: 69.00: 2.51: 21.51: 3.40: 9.91: 81.82 ...
The hand of an older adult Life expectancy in various countries of the world in 2019. Biogerontology is the sub-field of gerontology concerned with the biological aging process, its evolutionary origins, and potential means to intervene in the process. [1]
Klotho may refer to Klotho (Greek mythology) or Clotho, one of the Moirai, or Fates, in Greek mythology; 97 Klotho, an asteroid; Klotho (biology), a membrane protein;
Clotho (/ ˈ k l oʊ θ oʊ /; Greek: Κλωθώ) or Klotho, is a mythological figure. She is the youngest goddess of the Three Fates or Moirai. In ancient Greek mythology, she spins the thread of human life, her sisters draw out and cut the thread. She also made major decisions, such as when a person was born, thus in effect controlling people ...
This is especially true for Healthy life expectancy, the definition of which criteria may change over time, even within a country. For example, Canada is a country with a fairly high overall life expectancy at 81.63 years; however, this number decreases to 75.5 years for Indigenous people in the country. [4]