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CAS Number. 55-21-0 ... Benzamide is an organic compound with the chemical formula of C 7 H 7 NO. It is the simplest amide derivative of benzoic acid.
Enzomenib is an investigational new drug that is being evaluated for the treatment of acute leukemia. [1] It is a small molecule inhibitor that targets the interaction between menin and mixed-lineage leukemia (MLL) proteins. [2]
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Trimethobenzamide synthesis: Hoffmann La Roche, U.S. patent 2,879,293 (1959). Alkylation of the sodium salt of p-hydroxybenzaldehyde (1) with 2-dimethylaminoethyl chloride affords the ether (2).
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Nitazoxanide alone has shown preliminary evidence of efficacy in the treatment of chronic hepatitis B over a one-year course of therapy. [17] Nitazoxanide 500 mg twice daily resulted in a decrease in serum HBV DNA in all of 4 HBeAg-positive patients, with undetectable HBV DNA in 2 of 4 patients, loss of HBeAg in 3 patients, and loss of HBsAg in one patient.
Medulloblastoma [20] [21] Advanced solid tumors (including ovarian, breast, pancreatic, stomach, oesophageal cancers and glioblastoma multiforme) [22] [23] [24] Acute leukemia [25] and chronic myeloid leukemia [26] Myelofibrosis and essential thrombocythaemia [27] It has demonstrated significant efficacy against melanoma in vitro and in vivo. [28]