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Basal-cell carcinoma (BCC), also known as basal-cell cancer, basalioma [7] or rodent ulcer, [8] is the most common type of skin cancer. [2] It often appears as a painless raised area of skin, which may be shiny with small blood vessels running over it. [1] It may also present as a raised area with ulceration. [1]
A microscopic image of a prostate gland featuring an example of basal cells. A basal cell is a general cell type that is present in many forms of epithelial tissue throughout the body. Basal cells are located between the basement membrane and the remainder of the epithelium, effectively functioning as an anchor for the epithelial layer and an ...
A basal-cell skin cancer. Note the pearly appearance and telangiectasia. Specialty: Oncology and dermatology: Symptoms: Basal-cell: painless raised area of skin that may be shiny with small blood vessel running over it or ulceration [1] Squamous-cell: hard lump with a scaly top [2] Melanoma: mole that has changed in size, shape, color, or has ...
Skin cancer lesion removed from President Biden’s chest was identified as basal cell carcinoma Is the cancerous lesion removed from Biden dangerous and what is basal cell carcinoma? Skip to main ...
In humans, they constitute 90% of epidermal skin cells. [1] Basal cells in the basal layer (stratum basale) of the skin are sometimes referred to as basal keratinocytes. [2] Keratinocytes form a barrier against environmental damage by heat, UV radiation, water loss, pathogenic bacteria, fungi, parasites, and viruses.
The cells are attached to each other and to the overlying stratum spinosum cells by desmosomes and hemidesmosomes. The nucleus is large, ovoid and occupies most of the cell. Some basal cells can act like stem cells with the ability to divide and produce new cells, and these are sometimes called basal keratinocyte stem cells.
Myoepithelial cells in these cases constitute the basal cell layer of an epithelium that harbors the epithelial progenitor. In the case of wound healing, myoepithelial cells reactively proliferate . Presence of myoepithelial cells in a hyperplastic tissue proves the benignity of the gland and, when absent, indicates cancer .
The basal layer is a stem cell layer and through asymmetrical divisions, becomes the source of skin cells throughout life. It is maintained as a stem cell layer through an autocrine signal, TGF alpha , and through paracrine signaling from FGF7 ( keratinocyte growth factor ) produced by the dermis below the basal cells.
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